Literature summary for 2.3.2.31 extracted from

Johansson, H.; Tsai, Y.; Fantom, K.; Chung, C.; Kaemper, S.; Martino, L.; Thomas, D.; Eberl, H.; Muelbaier, M.; House, D.; Rittinger, K.
Fragment-based covalent ligand screening enables rapid discovery of inhibitors for the RBR E3 ubiquitin ligase HOIP (2020), J. Am. Chem. Soc., 141, 2703-2712 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
methyl (2E)-4-[(2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonyl)amino]but-2-enoate	labels RNF31 with proteome-wide selectivity and effectively inhibits linear polyubiquitin chain formation in vitro and in cells	Homo sapiens
methyl (2E)-4-[(2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carbonyl)amino]but-2-enoate	compound labels RNF31 RBR at the active site cysteine residue C885 in a time- and concentration-dependent manner. It effectively penetrates mammalian cells to inhibit RNF31 and NF-kappaB activation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96EP0	isoform RNF31	-

Synonyms

Synonyms	Comment	Organism
HOIP	-	Homo sapiens
RNF31	-	Homo sapiens

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Release 2023.1 (January 2023)