Literature summary for 2.3.2.27 extracted from

Chasapis, C.T.
Hierarchical core decomposition of RING structure as a method to capture novel functional residues within RING-type E3 ligases a structural systems biology approach (2018), Comput. Biol. Med., 100, 86-91 .

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Application

Application	Comment	Organism
analysis	development of a structure decomposition method that utilizes network analysis and computational thermodynamic measures of fold stability changes upon amino acids alterations	Homo sapiens
medicine	successive pruning of the RING structure network of cancer-associated E3 enzymes BRCA1, MDM2, and cIAP2 leads to a core for each RING domain. Substitutions of core residues are associated with cancers according to COSMIC catalog. 80% of the residues located in the core RING subnetworks are nonconserved within E3 RING domains. Core residues for BRCA1 are Thr37, Lys38, Ile68 and Leu73	Homo sapiens
medicine	successive pruning of the RING structure network of cancer-associated E3 enzymes BRCA1, MDM2, and cIAP2 leads to a core for each RING domain. Substitutions of core residues are associated with cancers according to COSMIC catalog. 80% of the residues located in the core RING subnetworks are nonconserved within E3 RING domains. Core residues for cIAP2 are Ser566, I567, Val568, Arg600 and Thr601	Homo sapiens
medicine	successive pruning of the RING structure network of cancer-associated E3 enzymes BRCA1, MDM2, and cIAP2 leads to a core for each RING domain. Substitutions of core residues are associated with cancers according to COSMIC catalog. 80% of the residues located in the core RING subnetworks are nonconserved within E3 RING domains. Core residues for MDM2 are Pro437, Asn447, Gly448, Ala460, Cys461, Ile485	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P38398	isoform BRCA1	-
Homo sapiens	Q00987	isoform MDM2	-
Homo sapiens	Q13489	isoform cIAP2	-

Synonyms

Synonyms	Comment	Organism
BIRC3	-	Homo sapiens
cIAP2	-	Homo sapiens

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Release 2023.1 (January 2023)