Literature summary for 2.3.2.27 extracted from

Jiang, J.; Bellani, M.; Li, L.; Wang, P.; Seidman, M.M.; Wang, Y.
Arsenite binds to the RING finger domain of FANCL E3 ubiquitin ligase and inhibits DNA interstrand crosslink repair (2017), ACS Chem. Biol., 12, 1858-1866 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
As3+	As3+ can bind to the PHD/RING finger domain of FANCL in vitro and in cells. This binding leads to compromised ubiquitination of FANCD2 in cells and diminishes recruitment of FANCD2 to chromatin and DNA damage sites induced by 4,5',8-trimethylpsoralen plus UVA irradiation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NW38	isoform FANCL	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [FANCD2]-L-lysine	-	Homo sapiens	[E2 ubiquitin-conjugating enzyme]-L-cysteine + [FANCD2]-N6-ubiquitinyl-L-lysine	-	?

Synonyms

Synonyms	Comment	Organism
FANCL	-	Homo sapiens

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Release 2023.1 (January 2023)