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Literature summary for 2.3.2.26 extracted from

  • Safdar, K.; Gu, A.; Xu, X.; Au, A.; Taylor, J.; Flibotte, S.; Moerman, D.G.; Maine, E.M.
    UBR-5, a conserved HECT-type E3 ubiquitin ligase, negatively regulates notch-type signaling in Caenorhabditis elegans (2016), G3 (Bethesda), 6, 2125-2134 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.26

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans G5EDT9
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Synonyms

Synonyms Comment Organism
sog-1
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 Caenorhabditis elegans
UBR E3 ubiquitin ligase homolog
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 Caenorhabditis elegans
Ubr-5
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 Caenorhabditis elegans

General Information

General Information Comment Organism
physiological function loss of Ubr-5 function suppresses defects caused by reduced signaling via Notch-type receptors GLP-1 or LIN-12. Ubr-5 mutations do not suppress embryonic or larval lethality associated with mutations in downstream transcription factor, LAG-1. In the gonad, Ubr-5 acts in the receiving cells (germ cells) to limit GLP-1 signaling activity. Ubr-5 acts redundantly with the F-box component of SCFSEL-10 E3 ubiquitin-ligase SEL-10 to limit Notch signaling in certain tissues Caenorhabditis elegans