Literature summary for 2.3.1.B41 extracted from

Cai, J.; Liu, Z.; Huang, X.; Shu, S.; Hu, X.; Zheng, M.; Tang, C.; Liu, Y.; Chen, G.; Sun, L.; Liu, H.; Liu, F.; Cheng, J.; Dong, Z.
The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking beta-catenin targetgene expression (2020), Kidney Int., 97, 106-118 .

Search for more literature for 2.3.1.B41

Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme knockout by SIRT6 siRNA expression. SIRT6 overexpression in hepatocellular carcinoma cells reduces E-cadherin levels	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + [protein]-N6-palmitoyl-L-lysine	Homo sapiens	-	nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N6T7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BEL-7402 cell	-	Homo sapiens	-
HCCLM-3 cell	-	Homo sapiens	-
HEP-3B cell	-	Homo sapiens	-
hepatoma cell	HCC cell, SIRT6 upregulation is quite prevalent in HCC tissues and closely correlated with worse overall survival, disease-relapse free survival, and HCC metastasis	Homo sapiens	-
HL-7702 cell	-	Homo sapiens	-
liver	-	Homo sapiens	-
MHCC-97H cell	-	Homo sapiens	-
MHCC97-L cell	-	Homo sapiens	-
additional information	SIRT6 promoted HCC metastasis, expression analysis in HCC cell lines, overview. SIRT6 expression is significantly increased. SIRT6 is also upregulated in Hep3B and LO2 cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + [protein]-N6-palmitoyl-L-lysine	-	Homo sapiens	nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose	-	?

Synonyms

Synonyms	Comment	Organism
deacetylase sirtuin 6	-	Homo sapiens
SIRT6	-	Homo sapiens
Sirtuin6	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

General Information

General Information	Comment	Organism
evolution	sirtuin6 is a member of the sirtuin family which function as NAD+-dependent deacetylases	Homo sapiens
malfunction	E-cadherin degradation and invasion, migration induced by SIRT6 overexpression can be rescued by dual mutation of Beclin-1 (inhibition of acetylation), CQ (autophagy inhibitor), and knockdown of Atg7	Homo sapiens
physiological function	sirtuin6 (SIRT6) is an NAD+-dependent deacetylase that targets a variety of proteins to regulate cellular processes and activities. Sirtuin family members are essential for tumor metastasis and epithelial-mesenchymal transition (EMT). Analysis of the mechanism by which SIRT6 facilitates EMT and metastasis, mechanism, overview. SIRT6 promotes HCC cell migration, invasion, and EMT. SIRT6 deacetylates Beclin-1 in HCC cells and this event leads to the promotion of the autophagic degradation of E-cadherin. SIRT6 also promotes N-cadherin and Vimentin expression via deacetylating FOXO3a in HCC. SIRT6 promotes the E-cadherin degradation in HCC via the lysosomal pathway, SIRT6 promotes the autophagic degradation of E-cadherin by deacetylating Beclin-1	Homo sapiens

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Release 2023.1 (January 2023)