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Literature summary for 2.3.1.B41 extracted from

  • Garcia-Peterson, L.; Ndiaye, M.; Singh, C.; Chhabra, G.; Huang, W.; Ahmad, N.
    SIRT6 histone deacetylase functions as a potential oncogene in human melanoma (2017), Genes Cancer, 8, 701-712 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B41

Protein Variants

Protein Variants Comment Organism
additional information lentiviral short hairpin RNA-mediated knockdown of SIRT6 in A-375 and Hs 294T human melanoma cells significantly decreased cell growth, viability, and colony formation, induced G1-phase arrest and increased senescence-associated beta-galactosidase staining. SIRT6 knockdown in A375 cells causes significant modulation in several genes and/or proteins, i.e. it decreases in AKT1, ATG12, ATG3, ATG7, BAK1, BCL2L1, CLN3, CTSB, CTSS, DRAM2, HSP90AA1, IRGM, NPC1, SQSTM1, TNF, and BECN1 expression and increases in GAA, ATG10 expression Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N6T7
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-

Source Tissue

Source Tissue Comment Organism Textmining
A-375 cell
-
 Homo sapiens
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G-361 cell
-
 Homo sapiens
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HS-294T cell
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 Homo sapiens
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melanocyte
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 Homo sapiens
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melanoma cell overexpression of SIRT6 in human melanoma tissues Homo sapiens
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additional information most of the melanoma cell lines exhibit significantly higher expression of SIRT6 protein and mRNA as assessed by immunoblot and RT-qPCR analyses, respectively Homo sapiens
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SK-MEL-2 cell
-
 Homo sapiens
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SK-MEL-28 cell
-
 Homo sapiens
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skin
-
 Homo sapiens
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WM-115 cell
-
 Homo sapiens
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WM-35 cell
-
 Homo sapiens
-
WM-451Lu cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
histone deacetylase
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 Homo sapiens
SIRT6
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 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction SIRT6 knockdown inhibits growth and clonogenic survival of A-375 and Hs-294T human melanoma cell lines, SIRT6 knockdown inhibits proliferation and colony formation in melanoma cells. SIRT6 knockdown results in an enhanced accumulation of cells in G0/G1 phase in both A-375 and Hs-294T human melanoma cell lines, it induces G1-phase arrest and senescence-like phenotypes in human melanoma cells. Modulations in autophagy-related genes are associated with the antiproliferative response of SIRT6 inhibition. Phenotype, overview Homo sapiens
physiological function SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. Autophagy is important in melanoma and is associated with SIRT6. Increased SIRT6 expression may contribute to melanoma development and/or progression, potentially via senescence- and autophagy-related pathways Homo sapiens