Literature summary for 2.3.1.B41 extracted from

Cui, X.; Yao, L.; Yang, X.; Gao, Y.; Fang, F.; Zhang, J.; Wang, Q.; Chang, Y.
SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK (2017), Am. J. Physiol. Endocrinol. Metab., 313, E493-E505 .

Search for more literature for 2.3.1.B41

Cloned(Commentary)

Cloned (Comment)	Organism
expression analysis of wild-type SIRT6flox/flox gene	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of muscle-specific knockout mice SIRT6M -/- and effects of different diets, phenotypes, detailed overview	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P59941	-	-
Mus musculus C57BL/6	P59941	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
C2C12 cell	-	Mus musculus	-
gastrocnemius	-	Mus musculus	-
muscle fibre	-	Mus musculus	-
myoblast	-	Mus musculus	-
skeletal muscle	-	Mus musculus	-
soleus	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
SIRT6	-	Mus musculus
sirtuin 6	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	SIRT6 protein levels are not detectable in skeletal muscle (gastrocnemius and soleus) in SIRT6M -/- mice and unchanged in other tissues related to metabolic homeostasis compared with SIRT6flox/flox control mice. Mutant phenotype includes attenuated whole body energy expenditure and weakened exercise performance. Mutant mice show inactive behavior with aging, decreased activity of AMPK and reduced expression of its downstream genes in skeletal muscle of SIRT6 knockout mutant mice. Basal mitochondrial respiration and maximal mitochondrial respiratory capacity increase in C2C12 myotubes overexpressing SIRT6	Mus musculus
physiological function	SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK. AMPK mediates the SIRT6 effects. SIRT6 regulates AMPK activity and oxidation capacity in C2C12 myotubes	Mus musculus

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Release 2023.1 (January 2023)