Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a therapeutic target for ovarian cancer therapy | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N6T7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ovarian cancer cell | - |
Homo sapiens | - |
OVCAR-3 cell | - |
Homo sapiens | - |
SKOV-3 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
SIRT6 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dependent on | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme expression is significantly reduced in human ovarian cancer tissues compared to the normal tissues | down |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme overexpression inhibits the proliferation of ovarian cancer cells SKOV-3 and OVCAR-3. The enzyme suppresses the expression of Notch 3 both at the mRNA and protein levels in ovarian cancer cells | Homo sapiens |