Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [protein]-N6-palmitoyl-L-lysine | Homo sapiens | - |
nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N6T7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
hepatocellular carcinoma cell | - |
Homo sapiens | - |
Huh-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [protein]-N6-palmitoyl-L-lysine | - |
Homo sapiens | nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SIRT6 | - |
Homo sapiens |
sirtuin 6 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dependent on | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme expression in HCC cells is upregulated by transforming growth factor-beta1, H2O2, and HOCl | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the upregulation of SIRT6 expression is required for transforming growth factor-beta1 and H2O2 /HOCl reactive oxygen species to promote the tumorigenicity of hepatocellular carcinoma cells. The enzyme contributes to inhibitory effect of ERK pathway on cellular senescence | Homo sapiens |