Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
x * 42000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [histone H3]-N6-palmitoyl-L-lysine9 | Homo sapiens | - |
nicotinamide + [histone H3]-L-lysine + 2'-O-palmitoyl-ADP ribose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N6T7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
multiple myeloma cell | high expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [histone H3]-N6-palmitoyl-L-lysine9 | - |
Homo sapiens | nicotinamide + [histone H3]-L-lysine + 2'-O-palmitoyl-ADP ribose | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 42000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
protein-long-chain fatty-acyl-lysine deacylase | - |
Homo sapiens |
Sir2A | - |
Homo sapiens |
SIRT6 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dependent on | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibiting SIRT6 activity enhances anti-multiple myeloma activity of doxorubicin in vivo | Homo sapiens |
physiological function | SIRT6 downregulates the expression of mitogen-activated protein kinase pathway genes, signaling, and proliferation. In addition, inactivation of ERK2/p90RSK signaling triggered by high SIRT6 levels increases DNA repair via Chk1 and confers resistance to DNA damage | Homo sapiens |