0.0009
[histone H3 peptide]-N6-palmitoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.0024
[synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine19
pH 8.0, 37°C
Homo sapiens
0.0034
[histone H3 peptide]-N6-myristoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.0045
[synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine20
pH 8.0, 37°C
Homo sapiens
0.04
[histone H3 peptide]-N6-octanoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.2
[histone H3 peptide]-N6-butyryl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.81
[histone H3 peptide]-N6-acetyl-L-lysine
pH 8.0, 37°C
Homo sapiens
additional information
Sirt6 prefers long chain fatty acyl groups. Low deacetylase activity on histone H3 K9 and histone H3 K56. Selectivity for peptide sequence is not high
730464
Homo sapiens
?
NAD+ + [histone H3 peptide]-N6-acetyl-L-lysine
730464
Homo sapiens
nicotinamide + [histone H3 peptide]-L-lysine + 2'-O-acetyl-ADP-ribose
?
NAD+ + [histone H3 peptide]-N6-butyryl-L-lysine
730464
Homo sapiens
nicotinamide + [histone H3 peptide]-L-lysine + 2'-O-butyryl-ADP-ribose
?
NAD+ + [histone H3 peptide]-N6-myristoyl-L-lysine
730464
Homo sapiens
nicotinamide + [histone H3 peptide]-L-lysine + 2'-O-myristoyl-ADP-ribose
?
NAD+ + [histone H3 peptide]-N6-octanoyl-L-lysine
730464
Homo sapiens
nicotinamide + [histone H3 peptide]-L-lysine + 2'-O-octanoyl-ADP-ribose
?
NAD+ + [histone H3 peptide]-N6-palmitoyl-L-lysine
730464
Homo sapiens
nicotinamide + [histone H3 peptide]-L-lysine + 2'-O-palmitoyl-ADP-ribose
?
NAD+ + [synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine19
730464
Homo sapiens
nicotinamide + [synthetic tumor necrosis factor alpha peptide]-L-lysine19 + 2'-O-myristoyl-ADP-ribose
?
NAD+ + [synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine20
730464
Homo sapiens
nicotinamide + [synthetic tumor necrosis factor alpha peptide]-L-lysine20 + 2'-O-myristoyl-ADP-ribose
?
NAD+ + [tumor necrosis factor alpha]-N6-acyl-L-lysine20
SIRT6 promotes the secretion of tumor necrosis factor alpha by removing the fatty acyl modification on K19 and K20 of TNFalpha
730464
Homo sapiens
nicotinamide + [tumor necrosis factor alpha]-L-lysine20 + 2'-O-acyl-ADP-ribose
?
NAD+ + [tumor necrosis factor alpha]-N6-myristoyl-L-lysine
730464
Homo sapiens
nicotinamide + [tumor necrosis factor alpha]-L-lysine + 2'-O-myristoyl-ADP-ribose
?
0.002
[synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine19
pH 8.0, 37°C
Homo sapiens
0.0021
[histone H3 peptide]-N6-butyryl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.0027
[histone H3 peptide]-N6-palmitoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.0039
[histone H3 peptide]-N6-acetyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.0046
[histone H3 peptide]-N6-octanoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.0049
[histone H3 peptide]-N6-myristoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.005
[synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine20
pH 8.0, 37°C
Homo sapiens
0.0009
[histone H3 peptide]-N6-palmitoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.0024
[synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine19
pH 8.0, 37°C
Homo sapiens
0.0034
[histone H3 peptide]-N6-myristoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.0045
[synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine20
pH 8.0, 37°C
Homo sapiens
0.04
[histone H3 peptide]-N6-octanoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.2
[histone H3 peptide]-N6-butyryl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.81
[histone H3 peptide]-N6-acetyl-L-lysine
pH 8.0, 37°C
Homo sapiens
additional information
Sirt6 prefers long chain fatty acyl groups. Low deacetylase activity on histone H3 K9 and histone H3 K56. Selectivity for peptide sequence is not high
730464
Homo sapiens
?
NAD+ + [histone H3 peptide]-N6-acetyl-L-lysine
730464
Homo sapiens
nicotinamide + [histone H3 peptide]-L-lysine + 2'-O-acetyl-ADP-ribose
?
NAD+ + [histone H3 peptide]-N6-butyryl-L-lysine
730464
Homo sapiens
nicotinamide + [histone H3 peptide]-L-lysine + 2'-O-butyryl-ADP-ribose
?
NAD+ + [histone H3 peptide]-N6-myristoyl-L-lysine
730464
Homo sapiens
nicotinamide + [histone H3 peptide]-L-lysine + 2'-O-myristoyl-ADP-ribose
?
NAD+ + [histone H3 peptide]-N6-octanoyl-L-lysine
730464
Homo sapiens
nicotinamide + [histone H3 peptide]-L-lysine + 2'-O-octanoyl-ADP-ribose
?
NAD+ + [histone H3 peptide]-N6-palmitoyl-L-lysine
730464
Homo sapiens
nicotinamide + [histone H3 peptide]-L-lysine + 2'-O-palmitoyl-ADP-ribose
?
NAD+ + [synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine19
730464
Homo sapiens
nicotinamide + [synthetic tumor necrosis factor alpha peptide]-L-lysine19 + 2'-O-myristoyl-ADP-ribose
?
NAD+ + [synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine20
730464
Homo sapiens
nicotinamide + [synthetic tumor necrosis factor alpha peptide]-L-lysine20 + 2'-O-myristoyl-ADP-ribose
?
NAD+ + [tumor necrosis factor alpha]-N6-acyl-L-lysine20
SIRT6 promotes the secretion of tumor necrosis factor alpha by removing the fatty acyl modification on K19 and K20 of TNFalpha
730464
Homo sapiens
nicotinamide + [tumor necrosis factor alpha]-L-lysine20 + 2'-O-acyl-ADP-ribose
?
NAD+ + [tumor necrosis factor alpha]-N6-myristoyl-L-lysine
730464
Homo sapiens
nicotinamide + [tumor necrosis factor alpha]-L-lysine + 2'-O-myristoyl-ADP-ribose
?
0.002
[synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine19
pH 8.0, 37°C
Homo sapiens
0.0021
[histone H3 peptide]-N6-butyryl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.0027
[histone H3 peptide]-N6-palmitoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.0039
[histone H3 peptide]-N6-acetyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.0046
[histone H3 peptide]-N6-octanoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.0049
[histone H3 peptide]-N6-myristoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.005
[synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine20
pH 8.0, 37°C
Homo sapiens
0.0048
[histone H3 peptide]-N6-acetyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.01
[histone H3 peptide]-N6-butyryl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.12
[histone H3 peptide]-N6-octanoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.14
[histone H3 peptide]-N6-myristoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.83
[synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine19
pH 8.0, 37°C
Homo sapiens
1.1
[synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine20
pH 8.0, 37°C
Homo sapiens
3
[histone H3 peptide]-N6-palmitoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.0048
[histone H3 peptide]-N6-acetyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.01
[histone H3 peptide]-N6-butyryl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.12
[histone H3 peptide]-N6-octanoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.14
[histone H3 peptide]-N6-myristoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
0.83
[synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine19
pH 8.0, 37°C
Homo sapiens
1.1
[synthetic tumor necrosis factor alpha peptide]-N6-myristoyl-L-lysine20
pH 8.0, 37°C
Homo sapiens
3
[histone H3 peptide]-N6-palmitoyl-L-lysine
pH 8.0, 37°C
Homo sapiens
737930
Cea
Evidence for a role of the his ...
Homo sapiens
Blood
127
1138-1150
2016
-
-
-
-
-
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
-
-
1
1
3
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
738060
Rahnasto-Rilla
N-acylethanolamines bind to SI ...
Homo sapiens
ChemBioChem
17
77-81
2016
12
-
1
-
-
-
3
1
-
-
-
2
-
1
-
-
1
-
-
-
-
-
3
-
2
-
-
-
-
-
-
-
1
-
-
2
12
-
1
1
-
-
-
2
3
-
1
-
-
-
2
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739139
Zhang
Identifying the functional con ...
Homo sapiens
Nat. Chem. Biol.
12
614-620
2016
-
-
1
-
4
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
4
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
739158
Tasselli
SIRT6 deacetylates H3K18Ac at ...
Homo sapiens
Nat. Struct. Mol. Biol.
23
434-440
2016
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
739225
Liu
Cyclic peptide-based potent hu ...
Homo sapiens
Org. Biomol. Chem.
14
5928-5935
2016
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
730473
Cardinale
Biochemical characterization o ...
Mus musculus
Neurochem. Res.
40
59-69
2015
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
737946
Hwang
SIRT6 protein deacetylase inte ...
Mus musculus
BMC Mol. Biol.
16
12
2015
-
-
1
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737977
Feng
Sirtuin 6 promotes transformin ...
Homo sapiens
Cancer Sci.
106
559-566
2015
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
3
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
738169
Zhang
The histone deacetylase SIRT6 ...
Homo sapiens
Eur. Rev. Med. Pharmacol. Sci.
19
818-824
2015
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
738170
Maksin-Matveev
Sirtuin 6 protects the heart f ...
Mus musculus
Exp. Cell Res.
330
81-90
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
738283
Hu
Posttranslational modification ...
Homo sapiens
Free Radic. Biol. Med.
79
176-185
2015
-
-
1
-
4
-
1
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
4
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739132
Etchegaray
The histone deacetylase SIRT6 ...
Mus musculus
Nat. Cell Biol.
17
545-557
2015
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
1
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
739733
Tian
Sirtuin-6 inhibits cardiac fib ...
Rattus norvegicus
Transl. Res.
165
374-386
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
729145
Chen
The histone deacetylase SIRT6 ...
Homo sapiens
Biochem. Biophys. Res. Commun.
446
364-369
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
729362
Liu
Oxidative stress induces endot ...
Homo sapiens
Biomed Res. Int.
2014
0000
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
729520
Ming
SIRT6 promotes COX-2 expressio ...
Homo sapiens, Mus musculus
Cancer Res.
74
5925-5933
2014
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
4
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
3
3
1
-
-
729679
Kokkonen
Studying SIRT6 regulation usin ...
Homo sapiens
Eur. J. Pharm. Sci.
0
0000
2014
-
-
-
-
-
-
12
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
5
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
729849
Wu
Expression and function of SIR ...
Homo sapiens
Int. J. Clin. Exp. Pathol.
7
6504-6513
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
730790
Silberman
SIRT6 is required for normal r ...
Homo sapiens
PLoS One
9
e98831
2014
-
-
-
-
-
-
-
-
-
-
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6
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730464
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730498
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4
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730949
Piao
Sirt6 regulates postnatal grow ...
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730706
Fischer
Sirt5 deacylation activities s ...
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730391
Avalos
Mechanism of sirtuin inhibitio ...
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