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Literature summary for 2.3.1.B41 extracted from

  • Merrick, C.J.; Duraisingh, M.T.
    Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity (2007), Eukaryot. Cell, 6, 2081-291.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B41

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is unaffected by the activators isonicotinamide and resveratrol Plasmodium falciparum

Application

Application Comment Organism
medicine PfSir2A inhibitors may have therapeutic value in malaria treatment Plasmodium falciparum

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli with a C-terminal His6 tag and an N-terminal T7 tag Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
additional information splitomicin and sirtinol fail to inhibit PfSir2 Plasmodium falciparum
nicotinamide inhibits the deacetylation of native histones much more effectively than deacetylation of a synthetic substrate Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 x * 30000, SDS-PAGE Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q8IE47
-
-
Plasmodium falciparum isolate 3D7 Q8IE47
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [histone H3]-N6-acetyl-L-lysine
-
 Plasmodium falciparum nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [histone H3]-N6-acetyl-L-lysine
-
 Plasmodium falciparum isolate 3D7 nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [histone H4]-N6-acetyl-L-lysine
-
 Plasmodium falciparum nicotinamide + [histone H4]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [histone H4]-N6-acetyl-L-lysine
-
 Plasmodium falciparum isolate 3D7 nicotinamide + [histone H4]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Subunits

Subunits Comment Organism
? x * 30000, SDS-PAGE Plasmodium falciparum

Synonyms

Synonyms Comment Organism
Sir2A
-
 Plasmodium falciparum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Plasmodium falciparum