Literature summary for 2.3.1.86 extracted from

Gajewski, J.; Pavlovic, R.; Fischer, M.; Boles, E.; Grininger, M.
Engineering fungal de novo fatty acid synthesis for short chain fatty acid production (2017), Nat. Commun., 8, 14650 .

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Protein Variants

Protein Variants	Comment	Organism
I306A/G1250S	mutant displays best production of hexanoic acid, accounting for 90% of measured short-chain fatty acids, yield is 20 mg/l	Saccharomyces cerevisiae
I306A/G1250S/M1250W	mutant displays increased synthesis of short-chain fatty acids, yield is up to 66 mg/l	Saccharomyces cerevisiae
I306A/R1834K/F1279Y	mutant displays best production of octanoic acid, yield is 48 mg/l	Saccharomyces cerevisiae
I306A/R1834K/G1250S	mutant displays increased synthesis of short-chain fatty acids, yield is up to 118 mg/l	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P07149 and P19097	P07149 i.e. subunit FAS1, P19097 i.e. subunit FAS2	-

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Release 2023.1 (January 2023)