Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Sphingomonas paucimobilis |
expressed in Saccharomyces cerevisiae DELTAlcb1 strain | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.56 | - |
L-serine | at pH 8.1 and 37°C | Sphingomonas paucimobilis | |
1.79 | - |
[1,2,3-13C,2-15N] L-serine | at pH 8.1 and 37°C | Sphingomonas paucimobilis | |
2.72 | - |
[3,3-D] L-serine | at pH 8.1 and 37°C | Sphingomonas paucimobilis | |
3.64 | - |
[2-13C] L-serine | at pH 8.1 and 37°C | Sphingomonas paucimobilis | |
4.09 | - |
[2,3,3-D] L-serine | at pH 8.1 and 37°C | Sphingomonas paucimobilis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-serine | Sphingomonas paucimobilis | - |
CoA + 3-dehydro-D-sphinganine + CO2 | - |
? | |
palmitoyl-CoA + L-serine | Homo sapiens | - |
CoA + 3-dehydro-D-sphinganine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15269 AND O15270 AND Q969W0 | subunit LCB1 and LCB2 and ssSPTa | - |
Sphingomonas paucimobilis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
nickel resin column chromatography | Homo sapiens |
Superdex S200 gel filtration | Sphingomonas paucimobilis |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0104 | - |
with [2,3,3-D] L-serine as cosubstrate, at pH 8.1 and 37°C | Homo sapiens |
0.0113 | - |
with[2-13C] L-serine as cosubstrate, at pH 8.1 and 37°C | Homo sapiens |
0.0116 | - |
with L-serine as cosubstrate, at pH 8.1 and 37°C | Homo sapiens |
0.0122 | - |
with [3,3-D] L-serine as cosubstrate, at pH 8.1 and 37°C | Homo sapiens |
0.0129 | - |
with [1,2,3-13C,2-15N] L-serine as cosubstrate, at pH 8.1 and 37°C | Homo sapiens |
0.177 | - |
with [2,3,3-D] L-serine as cosubstrate, at pH 8.1 and 37°C | Sphingomonas paucimobilis |
0.386 | - |
with L-serine as cosubstrate, at pH 8.1 and 37°C | Sphingomonas paucimobilis |
0.397 | - |
with [3,3-D] L-serine as cosubstrate, at pH 8.1 and 37°C | Sphingomonas paucimobilis |
0.411 | - |
with [2-13C] L-serine as cosubstrate, at pH 8.1 and 37°C | Sphingomonas paucimobilis |
0.441 | - |
with [1,2,3-13C,2-15N] L-serine as cosubstrate, at pH 8.1 and 37°C | Sphingomonas paucimobilis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-serine | - |
Sphingomonas paucimobilis | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? | |
palmitoyl-CoA + L-serine | - |
Homo sapiens | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? | |
palmitoyl-CoA + [1,2,3-13C,2-15N] L-serine | - |
Sphingomonas paucimobilis | ? | - |
? | |
palmitoyl-CoA + [1,2,3-13C,2-15N] L-serine | - |
Homo sapiens | ? | - |
? | |
palmitoyl-CoA + [2,3,3-D] L-serine | - |
Sphingomonas paucimobilis | ? | - |
? | |
palmitoyl-CoA + [2,3,3-D] L-serine | - |
Homo sapiens | ? | - |
? | |
palmitoyl-CoA + [2-13C] L-serine | - |
Sphingomonas paucimobilis | ? | - |
? | |
palmitoyl-CoA + [2-13C] L-serine | - |
Homo sapiens | ? | - |
? | |
palmitoyl-CoA + [3,3-D] L-serine | - |
Sphingomonas paucimobilis | ? | - |
? | |
palmitoyl-CoA + [3,3-D] L-serine | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LCB1 | subunit | Sphingomonas paucimobilis |
LCB1 | subunit | Homo sapiens |
LCB2 | subunit | Sphingomonas paucimobilis |
LCB2 | subunit | Homo sapiens |
serine palmitoyltransferase | - |
Sphingomonas paucimobilis |
serine palmitoyltransferase | - |
Homo sapiens |
SPT | - |
Sphingomonas paucimobilis |
SPT | - |
Homo sapiens |
ssSPTa | subunit | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Sphingomonas paucimobilis | |
pyridoxal 5'-phosphate | - |
Homo sapiens |