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Literature summary for 2.3.1.5 extracted from
- Subcellular protein labeling by a spatially restricted arylamine N-acetyltransferase (2018), ACS Chem. Biol., 13, 1932-1937 .
Application
| Application | Comment | Organism |
|---|---|---|
| analysis | the NAT enzyme activates an arylhydroxamic acid functionality into a nitrenium ion that reacts fast, covalently, and under neutral conditions with nucleophilic residues of neighboring proteins. Strong labeling is only observed with an arylhydroxamic acid bearing an electron donating substituent. Clear labeling is achieved on a subcellular level in living cells that are transfected with a genetically targeted NAT to the nucleus or the cytosol | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P18440 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a protein + 1-[4-[(6-azidohexyl)oxy]phenyl]-1-hydroxypropan-2-one | - |
Homo sapiens | ? | - |
? |  |
| a protein + 5-azido-N-[[4-(1-hydroxy-2-oxopropyl)phenyl]methyl]pentanamide | - |
Homo sapiens | ? | - |
? | |
| a protein + N-(5-azidopentyl)-4-(1-hydroxy-2-oxopropyl)benzamide | - |
Homo sapiens | ? | - |
? | |
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