Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli Rosetta(DE3)pLysS cells | Mus musculus |
expressed in Escherichia coli Rosetta(DE3)pLysS cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-[3-(3,5-dimethylanilino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]benzenesulfonamide | 93.3% inhibition of isoform NAT1 at 0.03 mM and 10.6% inhibition of isoform NAT2 | Homo sapiens | |
N-[3-(3,5-dimethylanilino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]benzenesulfonamide | 37.6% inhibition of isoform Nat1 at 0.03 mM and 92.4% inhibition of isoform Nat2 | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + an arylamine | Mus musculus | - |
CoA + an N-acetylarylamine | - |
? | |
acetyl-CoA + an arylamine | Homo sapiens | - |
CoA + an N-acetylarylamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography | Mus musculus |
Ni-NTA column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + an arylamine | - |
Mus musculus | CoA + an N-acetylarylamine | - |
? | |
acetyl-CoA + an arylamine | - |
Homo sapiens | CoA + an N-acetylarylamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAT1 | isoform | Mus musculus |
NAT1 | isoform | Homo sapiens |
NAT2 | isoform | Mus musculus |
NAT2 | isoform | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0019 | - |
isoform Nat2, pH and temperature not specified in the publication | Mus musculus | N-[3-(3,5-dimethylanilino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]benzenesulfonamide | |
0.0053 | - |
isoform NAT1, pH and temperature not specified in the publication | Homo sapiens | N-[3-(3,5-dimethylanilino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]benzenesulfonamide |