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Literature summary for 2.3.1.48 extracted from

  • Liu, Y.; Bao, C.; Wang, L.; Han, R.; Beier, U.H.; Akimova, T.; Cole, P.A.; Dent, S.Y.R.; Hancock, W.W.
    Complementary roles of GCN5 and PCAF in Foxp3+ T-regulatory cells (2019), Cancers (Basel), 11, 554 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.48

Protein Variants

Protein Variants Comment Organism
additional information deletion of Gcn5, phenotype, overview Mus musculus
additional information deletion of PCAF, PCAF targeting in wild-type mice impairs inhibits Treg function in vitro and in vivo, phenotype, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + [protein]-L-lysine Mus musculus
-
 CoA + [protein]-N6-acetyl-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JHD1
-
-
Mus musculus Q9JHD2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information colocalization of Foxp3 and PCAF in nuclei of T-regulatory cells (Tregs) Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + [protein]-L-lysine
-
 Mus musculus CoA + [protein]-N6-acetyl-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
Gcn5
-
 Mus musculus
general control nonrepressed-protein 5
-
 Mus musculus
HAT
-
 Mus musculus
histone acetyltransferase
-
 Mus musculus
Kat2A
-
 Mus musculus
Kat2b
-
 Mus musculus
lysine acetyltransferase 2A
-
 Mus musculus
p300
-
 Mus musculus
P300/CBP-associated factor
-
 Mus musculus
PCAF
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Mus musculus

General Information

General Information Comment Organism
evolution three main histone/protein acetyltransferase (HAT) families, CBP/p300, GNAT (GCN5/PCAF) and MYST exist. GCN5 belongs to the GNAT family Mus musculus
evolution three main histone/protein acetyltransferase (HAT) families, CBP/p300, GNAT (GCN5/PCAF) and MYST exist. PCAF belongs to the GNAT family Mus musculus
malfunction deletion of Gcn5 or PCAF do not affect Treg development or suppressive function in vitro, but do affect inducible Treg (iTreg) development, and in vivo, abrogate Treg-dependent allograft survival. Deletion of either CBP or p300 results in only a modest decrease in Treg suppressive function. Activated CD4+T cell population in mesenteric lymph nodes of PCAF-/- mice, contribution of PCAF to iTreg development. PCAF deletion in Foxp3+ Treg cells causes lethal autoimmunity Mus musculus
malfunction deletion of Gcn5 or PCAF do not affect Treg development or suppressive function in vitro, but do affect inducible Treg (iTreg) development, and in vivo, abrogate Treg-dependent allograft survival. Mice lacking GCN5 show prolonged allograft survival, suggesting this HAT might be a target for epigenetic therapy in allograft recipients. Dual deletion of GCN5 and PCAF leads to decreased Treg stability and numbers in peripheral lymphoid tissues, and mice succumbed to severe autoimmunity by 3-4 weeks of life. Conditional deletion of GCN5 in the Tregs of GCN5flfFoxp3YFP-cre mice have no significant effect on T-cell numbers or their baseline level of immune activation. GCN5 deletion also decreases Teff cell functions in vivo. GCN5 deletion in Foxp3+ Treg cells causes lethal autoimmunity Mus musculus
metabolism two prototypical GNAT family members, GCN5 (general control nonrepressed-protein 5, lysine acetyltransferase (KAT)2a) and p300/CBP-associated factor (p300/CBP-associated factor (PCAF), Kat2b) contribute to Treg functions through partially distinct and partially overlapping mechanisms Mus musculus
metabolism two prototypical GNAT family members, GCN5 (general control nonrepressed-protein 5, lysine acetyltransferase (KAT)2a) and p300/CBP-associated factor (p300/CBP-associated factor (PCAF), Kat2b) contribute to Treg functions through partially distinct and partially overlapping mechanisms. Transplants in mice lacking PCAF undergo acute allograft rejection. PCAF deletion also enhances anti-tumor immunity in immunocompetent mice. Dual deletion of GCN5 and PCAF leads to decreased Treg stability and numbers in peripheral lymphoid tissues, and mice succumbed to severe autoimmunity by 3-4 weeks of life Mus musculus
physiological function histone acetyltransferases (HATs) play critical roles in controlling T-regulation (Treg) development Mus musculus
physiological function histone acetyltransferases (HATs) play critical roles in controlling T-regulation (Treg) development. PCAF helps protect Tregs from undergoing apoptosis upon TCR stimulation Mus musculus