Application | Comment | Organism |
---|---|---|
medicine | CBP/p300 could be a promising therapeutic target in hepatocellular carcinoma | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
C646 | CBP/p300-specific histone acetyltransferase inhibitor, that inhibits proliferation of hepatocellular carcinoma cell lines in a dose-dependent manner; CBP/p300-specific histone acetyltransferase inhibitor, that inhibits proliferation of hepatocellular carcinoma cell lines in a dose-dependent manner | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q09472 | p300 | - |
Homo sapiens | Q92793 | CBP | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
hepatocarcinoma cell | high expression รถevel of CBP/p300 in hepatocarcinoma tissue | Homo sapiens | - |
hepatoma HLE cell | - |
Homo sapiens | - |
SK-HEP-1 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
CREB binding protein | - |
Homo sapiens |
HAT | - |
Homo sapiens |
p300 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition significantly augments TRAIL-induced apoptotic sensitivity, which is accompanied by reduced levels of survivin, in Hep-G2, HLE and SK-HEP1 cells. Enzyme inhibition significantly decreases invasion of Huh7, HLE and SK-HEP1 cells. The level of matrix metallopeptidase 15 (MMP15) mRNA expression is significantly reduced, whereas the level of laminin alpha 3 (LAMA3) and secreted phosphoprotein 1 (SPP1) mRNA expression is significantly increased in Huh7 cells following exposure to enzyme inhibitor C646 | Homo sapiens |
physiological function | expression of p300, but not of CBP, is strongly correlated with the malignant character of hepatocellular carcinoma. CBP/p300 HAT activity has an important role in malignant transformation, proliferation, apoptotic sensitivity and invasion in hepatocellular carcinoma | Homo sapiens |