Literature summary for 2.3.1.300 extracted from

Cheon, D.; Lee, W.; Lee, Y.; Lee, J.; Kim, Y.
Structural basis of branched-chain fatty acid synthesis by Propionibacterium acnes beta-ketoacyl acyl carrier protein synthase (2019), Biochem. Biophys. Res. Commun., 509, 322-328 .

Search for more literature for 2.3.1.300

Crystallization (Commentary)

Crystallization (Comment)	Organism
mutant C122A, to 1.9 A resolution	Cutibacterium acnes

Protein Variants

Protein Variants	Comment	Organism
C122A	mutation of active-site residue, mutant displays much improved solubility	Cutibacterium acnes

Organism

Organism	UniProt	Comment	Textmining
Cutibacterium acnes	A0A2B7IGT3	cf. EC 2.3.1.180	-
Cutibacterium acnes KPA171202	A0A2B7IGT3	cf. EC 2.3.1.180	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
isobutanoyl-CoA + malonyl-[acyl-carrier protein]	-	Cutibacterium acnes	5-methyl-3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2	-	?
isobutanoyl-CoA + malonyl-[acyl-carrier protein]	-	Cutibacterium acnes KPA171202	5-methyl-3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2	-	?
isohexanoyl-CoA + malonyl-[acyl-carrier protein]	-	Cutibacterium acnes	? + CoA + CO2	-	?
isohexanoyl-CoA + malonyl-[acyl-carrier protein]	-	Cutibacterium acnes KPA171202	? + CoA + CO2	-	?
additional information	KAS III has distinctive substrate specificity and uses branched-chain acyl-CoA as well as long-chain acyl-CoA. KAS III can use butanoyl-, isobutanoyl-, and hexanoyl-CoA as preferred substrates over acetyl-CoA (reaction of EC 32.3.1.180)	Cutibacterium acnes	?	-	-
additional information	KAS III has distinctive substrate specificity and uses branched-chain acyl-CoA as well as long-chain acyl-CoA. KAS III can use butanoyl-, isobutanoyl-, and hexanoyl-CoA as preferred substrates over acetyl-CoA (reaction of EC 32.3.1.180)	Cutibacterium acnes KPA171202	?	-	-

Synonyms

Synonyms	Comment	Organism
FabH	-	Cutibacterium acnes
KAS III	-	Cutibacterium acnes

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Release 2023.1 (January 2023)