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Literature summary for 2.3.1.298 extracted from

  • Mizutani, Y.; Sun, H.; Ohno, Y.; Sassa, T.; Wakashima, T.; Obara, M.; Yuyama, K.; Kihara, A.; Igarashi, Y.
    Cooperative synthesis of ultra long-chain fatty acid and ceramide during keratinocyte differentiation (2013), PLoS ONE, 8, e67317 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.298

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells Mus musculus
expressed in HEK-293T cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an ultra-long-chain fatty acyl-CoA + a sphingoid base Mus musculus
-
 an ultra-long-chain ceramide + CoA
-
 ?
an ultra-long-chain fatty acyl-CoA + a sphingoid base Homo sapiens
-
 an ultra-long-chain ceramide + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Mus musculus
-
epidermis
-
 Homo sapiens
-
keratinocyte
-
 Mus musculus
-
keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an ultra-long-chain fatty acyl-CoA + a sphingoid base
-
 Mus musculus an ultra-long-chain ceramide + CoA
-
 ?
an ultra-long-chain fatty acyl-CoA + a sphingoid base
-
 Homo sapiens an ultra-long-chain ceramide + CoA
-
 ?
behenoyl-CoA + a sphingoid base
-
 Mus musculus behenoyl ceramide + CoA
-
 ?
behenoyl-CoA + a sphingoid base
-
 Homo sapiens behenoyl ceramide + CoA
-
 ?
hexacosanoyl-CoA + a sphingoid base
-
 Mus musculus hexacosanoyl ceramide + CoA
-
 ?
hexacosanoyl-CoA + a sphingoid base
-
 Homo sapiens hexacosanoyl ceramide + CoA
-
 ?

Subunits

Subunits Comment Organism
? x * 35000, SDS-PAGE Mus musculus
? x * 35000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
CerS3
-
 Mus musculus
CerS3
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus enzyme mRNA increases during keratinocyte differentiation up
Homo sapiens enzyme mRNA increases during keratinocyte differentiation up

General Information

General Information Comment Organism
malfunction enzyme knockdown causes a reduction in the elongase activities toward ultra-long-chain acyl-CoAs Mus musculus
malfunction enzyme knockdown causes a reduction in the elongase activities toward ultra-long-chain acyl-CoAs Homo sapiens
metabolism the enzyme positively regulates very-long chain and ultra-long-chain fatty acid synthesis in keratinocytes. The enzyme regulates activities of ELOVL1 and ELOVL4 in differentiated keratinocytes Mus musculus
metabolism the enzyme positively regulates very-long chain and ultra-long-chain fatty acid synthesis in keratinocytes. The enzyme regulates activities of ELOVL1 and ELOVL4 in differentiated keratinocytes Homo sapiens