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Literature summary for 2.3.1.298 extracted from

  • Jensen, J.M.; Forl, M.; Winoto-Morbach, S.; Seite, S.; Schunck, M.; Proksch, E.; Schutze, S.
    Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging (2005), Exp. Dermatol., 14, 609-618 .
    View publication on PubMed
Search for more literature for 2.3.1.298

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q1A3B0
-
-
Mus musculus SKH-1 Q1A3B0
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-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Mus musculus
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skin aged skin shows decreased levels of stratum corneum ceramides. Comparison of activities of epidermal A-SMase, ceramide synthase, and ceramidase in chronologically aged versus young hairless mouse skin. Reduced A-SMase and ceramide synthase activities are found in the epidermis of aged mice, but ceramidase activity is not age-dependent Mus musculus
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stratum corneum aged skin shows decreased levels of stratum corneum ceramides Mus musculus
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Synonyms

Synonyms Comment Organism
ceramide synthase
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 Mus musculus
ceramide synthase 3
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 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

General Information

General Information Comment Organism
physiological function epidermal ceramides are generated by sphingomyelin hydrolysis or synthesis from sphingosin and fatty acids and are degraded by ceramidase. In aged skin occur decreased levels of stratum corneum ceramides. Epidermal acid sphingomyelinase (A-SMase) generates ceramides with structural function in the stratum corneum lipid bilayers, which provide for the permeability barrier function of the skin. Reduced A-SMase and ceramide synthase activities are found in the epidermis of aged mice, but ceramidase activity is not age-dependent Mus musculus