Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] + 8 malonyl-CoA + 16 NADPH + 16 H+ | Mycobacterium tuberculosis | - |
17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 16 NADP+ + 8 H2O | - |
? | |
4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] + 9 malonyl-CoA + 18 NADPH + 18 H+ + holo-[4-hydroxyphenylalkanoate synthase] | Mycobacterium tuberculosis | - |
19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 18 NADP+ + 9 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P96284 | - |
- |
Mycobacterium tuberculosis | P96285 | - |
- |
Mycobacterium tuberculosis variant bovis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] + 8 malonyl-CoA + 16 NADPH + 16 H+ | - |
Mycobacterium tuberculosis | 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 16 NADP+ + 8 H2O | - |
? | |
4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] + 9 malonyl-CoA + 18 NADPH + 18 H+ + holo-[4-hydroxyphenylalkanoate synthase] | - |
Mycobacterium tuberculosis | 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 18 NADP+ + 9 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKS1 | - |
Mycobacterium tuberculosis variant bovis |
PKS1 | - |
Mycobacterium tuberculosis |
Pks15 | - |
Mycobacterium tuberculosis variant bovis |
Pks15 | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
physiological function | a single open reading frame for pks15/1 is found in Mycobacterium bovis BCG. Disruption of the pks15/1 gene leads to the abolition of the synthesis of type-specific phenolphthiocerol glycolipid | Mycobacterium tuberculosis variant bovis |
physiological function | polyketide synthase gene pks1 is involved in the elongation of 4hydroxybenzoic acid derivatives to form p-hydroxyphenylalkanoates, which in turn are converted, presumably by the PpsA-E synthase, to phenolphthiocerol derivatives. All the strains of Mycobacterium tuberculosis examined and deficient in the production of phenolphthiocerol derivatives are natural mutants with a frameshift mutation in pks1 | Mycobacterium tuberculosis |
physiological function | polyketide synthase gene pks15 is involved in the elongation of 4-hydroxybenzoic acid derivatives to form p-hydroxyphenylalkanoates, which in turn are converted, presumably by the PpsA-E synthase, to phenolphthiocerol derivatives. All the strains of Mycobacterium tuberculosis examined and deficient in the production of phenolphthiocerol derivatives are natural mutants with a frameshift mutation in pks15 | Mycobacterium tuberculosis |