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Literature summary for 2.3.1.26 extracted from

  • Zhan, Y.; Zhang, X.; Xiong, Y.; Li, B.; Nan, F.
    Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A Cholesterol acyltransferase 2 (ACAT2) (2016), Org. Biomol. Chem., 14, 747-751 .
    View publication on PubMed
Search for more literature for 2.3.1.26

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-[(5aR,6R,8R,9aR,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]propane-1,2-diyl diacetate compound exhibits potent activity against isoform ACAT2 and greater selectivity for ACAT2 than for ACAT1, ratio of IC50 value for ACTA1/ACAT2 is above 1000 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O75908
-
-

Synonyms

Synonyms Comment Organism
ACAT2
-
 Homo sapiens
Soat2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000077
-
 NBD22-steryl ester fluorescence assay, pH not specified in the publication, temperature not specified in the publication Homo sapiens (2S)-2-[(5aR,6R,8R,9aR,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]propane-1,2-diyl diacetate