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Literature summary for 2.3.1.26 extracted from

  • Kim, D.H.; Han, K.M.; Chung, I.S.; Kim, D.K.; Kim, S.H.; Kwon, B.M.; Jeong, T.S.; Park, M.H.; Ahn, E.M.; Baek, N.I.
    Triterpenoids from the flower of Campsis grandiflora K. Schum. as human acyl-CoA: cholesterol acyltransferase inhibitors (2005), Arch. Pharm. Res., 28, 550-556.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
2alpha,3beta,23-trihydroxyolean-12-en-28-oic acid arjunolic acid, at 0.1 mg/ml, 60.8% inhibition of isoform ACAT1, 5.3% inhibition of isoform ACAT2 Homo sapiens
2alpha,3beta-dihydroxyolean-12-en-28-oic acid maslinic acid, at 0.1 mg/ml, 46.2% inhibition of isoform ACAT1, 17.3% inhibition of isoform ACAT2 Homo sapiens
2alpha,3beta-dihydroxyurs-12-en-28-oic acid corosolic acid, at 0.1 mg/ml, 46.7% inhibition of isoform ACAT1, 3% inhibition of isoform ACAT2 Homo sapiens
3beta,23-dihydroxyurs-12-en-28-oic acid 23-hydroxyursolic acid, at 0.1 mg/ml, 41.5% inhibition of isoform ACAT1, 22.2% inhibition of isoform ACAT2 Homo sapiens
3beta-hydroxyolean-12-en-28-oic acid oleanoic acid, at 0.1 mg/ml, 22.6% inhibition of isoform ACAT1, 10.2% inhibition of isoform ACAT2 Homo sapiens
3beta-hydroxyurs-12-en-28-al ursolic aldehyde, at 0.1 mg/ml, 21.8% inhibition of isoform ACAT1, 13% inhibition of isoform ACAT2 Homo sapiens
3beta-hydroxyurs-12-en-28-oic acid ursolic acid, at 0.1 mg/ml, 23.1% inhibition of isoform ACAT1, 16.7% inhibition of isoform ACAT2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining