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Literature summary for 2.3.1.255 extracted from

  • Xu, H.; Han, Y.; Liu, B.; Li, R.
    Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-alpha-acetyltransferase 10 (Naa10) (2016), Sci. Rep., 6, 38508 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene NAA10, real-time reverse transcription-PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of Naa10 stably knocked down H1299 cell line H1299-shNaa10, cDNA microarray analysis Homo sapiens
additional information silencing of mouse immortalized embryonic endothelial cells Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens P41227
-
-
Mus musculus Q9QY36
-
-
Mus musculus C57 Q9QY36
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo caudal half region, immortalized embryonic endothelial cells Mus musculus
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endothelial cell immortalized embryonic endothelial cells Mus musculus
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NCI-H1299 cell
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 Homo sapiens
-

Synonyms

Synonyms Comment Organism
N-alpha-acetyltransferase 10
-
 Homo sapiens
N-alpha-acetyltransferase 10
-
 Mus musculus
NAA10
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 Homo sapiens
NAA10
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Homo sapiens
acetyl-CoA
-
 Mus musculus

General Information

General Information Comment Organism
malfunction measuring the different time points of gene expression upon Naa10 siRNA treatment, NTN1 and its receptor UNC5B are found to be the most dramatically overexpressed among the genes involved in morphogenesis Mus musculus
malfunction measuring the different time points of gene expression upon Naa10 siRNA treatment, NTN1 and its receptor UNC5B are found to be the most dramatically overexpressed among the genes involved in morphogenesis. Analysis of upregulated genes in Naa10 stably knocked down H1299 cell line, overview Homo sapiens
physiological function N-alpha-acetyltransferase 10 (Naa10) is the catalytic subunit of N-acetyltransferase A (NatA), it catalyzes N-alpha-acetylation, epsilon-acetylation, as well as autoacetylation. The alpha (N-terminal) acetyltransferase functions as a major modulator of cell growth and differentiation. Potential function of Naa10 in cell morphogenesis. Negative regulation of Naa10 towards NTN1 and its receptor UNC5B are detected upon treatment of all-trans retinoid acid, used to induce morphological differentiation. UNC-5 Homolog B (UNC5b), a dependence receptor of netrin-1, plays an essential role in mediating the repulsive effect of axonal migration and blood vessel formation through association with its ligand netrin-1 (NTN1). In addition, UNC5B has also been indicated as a putative tumor suppressor gene in numerous cancers Homo sapiens
physiological function N-alpha-acetyltransferase 10 (Naa10) is the catalytic subunit of N-acetyltransferase A (NatA), it catalyzes N-alpha-acetylation, epsilon-acetylation, as well as autoacetylation. The alpha (N-terminal) acetyltransferase functions as a major modulator of cell growth and differentiation. Potential function of Naa10 in cell morphogenesis. Negative regulation of Naa10 towards NTN1 and its receptor UNC5B are detected upon treatment of all-trans retinoid acid, usedto induce morphological differentiation. UNC-5 Homolog B (UNC5b), a dependence receptor of netrin-1, plays an essential role in mediating the repulsive effect of axonal migration and blood vessel formation through association with its ligand netrin-1 (NTN1). In addition, UNC5B has also been indicated as a putative tumor suppressor gene in numerous cancers Mus musculus