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Literature summary for 2.3.1.255 extracted from

  • Ochaya, S.; Franzen, O.; Buhwa, D.A.; Foyn, H.; Butler, C.E.; Stove, S.I.; Tyler, K.M.; Arnesen, T.; Matovu, E.; Aslund, L.; Andersson, B.
    Characterization of evolutionarily conserved Trypanosoma cruzi NatC and NatA-N-terminal acetyltransferase complexes (2019), J. Parasitol. Res., 2019, 6594212 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.255

Cloned(Commentary)

Cloned (Comment) Organism
genes TcNaa15 and TcNaa10, DNA and amino acid sequence determination, comparison, and analysis Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm TcNaa15 and TcNaa10 Trypanosoma cruzi 5737
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additional information TcNaa15 and TcNaa10 both proteins show nuclear and cytoplasmic location. TcNatC and TcNatA proteins physically interact with each other and it is plausible that this interaction takes place in the cytoplasm as suggested by their possible ribosomal cosedimentation. Subcellular localization of subunits, overview Trypanosoma cruzi
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nucleus TcNaa15 and TcNaa10 Trypanosoma cruzi 5634
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Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi Q4DSU6 AND Q4D0P4 an Esmeraldo-like catalytic NatA complex subunit ARD1/TcNaa10 and a non-Esmeraldo-like auxilliary NatA complex subunit Nat1/TcNaa15
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Trypanosoma cruzi CL Brener Q4DSU6 AND Q4D0P4 an Esmeraldo-like catalytic NatA complex subunit ARD1/TcNaa10 and a non-Esmeraldo-like auxilliary NatA complex subunit Nat1/TcNaa15
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Source Tissue

Source Tissue Comment Organism Textmining
amastigote
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 Trypanosoma cruzi
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epimastigote
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 Trypanosoma cruzi
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additional information the subunits forming the NatA enzyme complex, TcNaa10/TcNaa15, are expressed in the three main life cycle stages of the parasite, form stable complexes in vivo, and partially cosediment with the ribosome in agreement with a cotranslational function. Expression analysis of TcNaa10/TcNaa15 in the parasite Trypanosoma cruzi
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trypomastigote
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 Trypanosoma cruzi
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Subunits

Subunits Comment Organism
dimer the Trypanosoma cruzi Nat A protein complex consists of an Esmeraldo-like catalytic NatA complex subunit ARD1/TcNaa10 and a non-Esmeraldo-like auxilliary NatA complex subunit Nat1/TcNaa15 Trypanosoma cruzi

Synonyms

Synonyms Comment Organism
ARD1
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 Trypanosoma cruzi
NAA10
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 Trypanosoma cruzi
NAA15
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 Trypanosoma cruzi
NAT1
-
 Trypanosoma cruzi
NatA
-
 Trypanosoma cruzi
TcNatA
-
 Trypanosoma cruzi

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
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 assay at Trypanosoma cruzi

General Information

General Information Comment Organism
additional information Trypanosoma cruzi NatA protein complex consists of one catalytic subunit and one predicted auxiliary subunit. TcNatC (EC 2.3.1.256) and TcNatA complex subunits interact in vivo and in vitro Trypanosoma cruzi
physiological function TcNatC/TcNatA proteins carry out their function independently of each other as suggested in other organisms and they may have specific functions depending on the parasite life cycle stage. But the proteins may also have other functions independent of the NAT-activity as suggested in other species Trypanosoma cruzi