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Literature summary for 2.3.1.255 extracted from
- The biological functions of Naa10 - From amino-terminal acetylation to human disease (2015), Gene, 567, 103-131.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme is associated with Ogden syndrome | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 26000 | - |
- |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P41227 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
| HT-1080 cell | - |
Homo sapiens | - |
| U2OS cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Naa10 undergoes autoacetylation at lysine K136 | Homo sapiens | ? | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 26000, calculated from amino acid sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ARD1 | - |
Homo sapiens |
| arrest-defective protein 1 homologue | - |
Homo sapiens |
| DXS707 | - |
Homo sapiens |
| NAA10 | gene name, catalytic subunit of NatA | Homo sapiens |
| Nalpha-acetyltransferase 10 | - |
Homo sapiens |
| NatA | - |
Homo sapiens |
| TE2 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the expression of Naa10 increases during neuronal dendritic development of cerebellar Purkinje cells | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | knockdown of Naa10 in HeLa cells leads to apoptosis and sensitizes cells for daunorubicin-induced apoptosis | Homo sapiens |
| metabolism | Naa10 activates and/or amplifies the transcriptional activity of beta-catenin/TCF transcriptional activity thereby stimulating cyclin D1 and c-Myc expression leading to inhibition of p21WAF1/CIP1 and promoting the G1/S cell cycle transition. Naa10 is essential for the activation of caspase-2/-3/-7 and -9 in HeLa cells after doxorubicin stimulation | Homo sapiens |
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