Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8C172 | isoform CerS6 | - |
Mus musculus | Q9D6K9 | isoform CerS5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | - |
Mus musculus | - |
intestine | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | inhibition by fumosinin and siRNA for isoforms CerS5 or CerS6 suppresses myristate-induced C14-ceramide generation and XBP1 splicing. Increased XBP1 splicing induces the downstream expression of IL-6 in a CerS5/CerS6-dependent manner. A myristate-enriched milk fat-based diet, but not a lard-based diet, increases C14-ceramide, XBP1 splicing and IL-6 expression in vivo | Mus musculus |
physiological function | inhibition by fumosinin and siRNA for isoforms CerS5 or CerS6 suppresses myristate-induced C14-ceramide generation and XBP1 splicing. Increased XBP1 splicing induces the downstream expression of IL-6 in a CerS5/CerS6-dependent manner. A myristate-enriched milk fat-based diet, but not a lard-based diet, increases C14-ceramide,XBP1 splicing and IL-6 expression in vivo | Mus musculus |