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Literature summary for 2.3.1.181 extracted from
- Mis-targeting of the mitochondrial protein LIPT2 leads to apoptotic cell death (2017), PLoS ONE, 12, e0179591 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | A6NK58 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lipoyl(octanoyl) transferase 2 | - |
Homo sapiens |
| LIPT2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | first 31 amino acids of the N-terminus of LIPT2 represent a mitochondrial targeting sequence and inhibition of the transit of LIPT2 to the mitochondrion results in apoptotic cell death associated with activation of the apoptotic volume decrease current in normotonic conditions, as well as over-activation of the swelling-activated chloride current, mitochondrial membrane potential collapse, caspase-3 cleavage and nuclear DNA fragmentation | Homo sapiens |
| metabolism | the enzyme is involved in the post-translational modification of key energy metabolism enzymes in humans | Homo sapiens |
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