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Literature summary for 2.3.1.180 extracted from

  • Scarsdale, J.N.; Kazanina, G.; He, X.; Reynolds, K.A.; Wright, H.T.
    Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (2001), J. Biol. Chem., 276, 20516-20522.
    View publication on PubMed
Search for more literature for 2.3.1.180

Application

Application Comment Organism
drug development the enzyme represents a target for structure-based design of antimycobacterial agents Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
purified FabH, X-ray diffraction structure determination and analysis at 2.1 A resolution Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
myristoyl-CoA + malonyl-[acyl-carrier protein] Mycobacterium tuberculosis the enzyme plays a key role in initiation of the long-chain fatty acid route of meromycolic acid biosynthesis, a different enzyme with specificity for short-chain acyl-CoAs might also be responsible for meromycolic acid biosynthesis, biosynthetic pathway regulation mechanism 3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mycobacterium tuberculosis

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2 active site structure with a CoA/malonyl-ACP-binding channel leading from the enzyme surface to the buried active site Cys residue, a second channel leads from the active site to the surface with a threonine residue controlling the passage of longer acyl chains Mycobacterium tuberculosis
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myristoyl-CoA + malonyl-[acyl-carrier protein] the enzyme plays a key role in initiation of the long-chain fatty acid route of meromycolic acid biosynthesis, a different enzyme with specificity for short-chain acyl-CoAs might also be responsible for meromycolic acid biosynthesis, biosynthetic pathway regulation mechanism Mycobacterium tuberculosis 3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
myristoyl-CoA + malonyl-[acyl-carrier protein] the enzyme prefers long-chain acyl-CoA substrates for the Claisen condensation reaction Mycobacterium tuberculosis 3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2
-
 ?

Synonyms

Synonyms Comment Organism
beta-ketoacyl-acyl carrier protein synthase III
-
 Mycobacterium tuberculosis
FabH
-
 Mycobacterium tuberculosis