Literature summary for 2.3.1.176 extracted from

Cai, J.; Du, X.; Wang, C.; Lin, J.; Du, X.
Identification of potential Helicoverpa armigera (Lepidoptera Noctuidae) sterol carrier protein-2 inhibitors through high-throughput virtual screening (2017), J. Econ. Entomol., 110, 1779-1784 .

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Application

Application	Comment	Organism
agriculture	sterol carrier protein-2 is a validated target for development of novel insecticides due to its divergent protein structure and function from the vertebrate SCP-2. HaSCP-2 is important for normal development and fertility in Helicoverpa armigera. Chemical inhibitors of HaSCP-2 through a structure-based virtual screening are discovered. Bioassay indicates that H1 (N2,N7-di(1-naphthyl)-9H-2,7-fluorenedisulfonamide) and H14 (2,2'-diphenyl-4H,4'H-[6,6'-bibenzo[d][1,3]oxazine]-4,4'-dione) have inhibitory effect on the growth of Helicoverpa armigera larvae. H1 and H14 are promising as useful lead compounds for further optimization and development of novel SCP-2-specific pesticides	Helicoverpa armigera

Inhibitors

Inhibitors	Comment	Organism	Structure
2,2'-diphenyl-4H,4'H-[6,6'-bibenzo[d][1,3]oxazine]-4,4'-dione	sterol carrier protein-2 is a validated target for development of novel insecticides due to its divergent protein structure and function from the vertebrate SCP-2. HaSCP-2 is important for normal development and fertility in Helicoverpa armigera. H1 (N2,N7-di(1-naphthyl)-9H-2,7-fluorenedisulfonamide) and H14 (2,2'-diphenyl-4H,4'H-[6,6'-bibenzo[d][1,3]oxazine]-4,4'-dione) have inhibitory effect on the growth of Helicoverpa armigera larvae	Helicoverpa armigera
N2,N7-di(1-naphthyl)-9H-2,7-fluorenedisulfonamide	sterol carrier protein-2 is a validated target for development of novel insecticides due to its divergent protein structure and function from the vertebrate SCP-2. HaSCP-2 is important for normal development and fertility in Helicoverpa armigera. H1 (N2,N7-di(1-naphthyl)-9H-2,7-fluorenedisulfonamide) and H14 (2,2'-diphenyl-4H,4'H-[6,6'-bibenzo[d][1,3]oxazine]-4,4'-dione) have inhibitory effect on the growth of Helicoverpa armigera larvae	Helicoverpa armigera

Organism

Organism	UniProt	Comment	Textmining
Helicoverpa armigera	K7NSY9	-	-

Synonyms

Synonyms	Comment	Organism
HaSCP-2	-	Helicoverpa armigera
sterol carrier protein-2	-	Helicoverpa armigera

General Information

General Information	Comment	Organism
physiological function	the enzyme is important for normal development and fertility in Helicoverpa armigera	Helicoverpa armigera

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Release 2023.1 (January 2023)