Literature summary for 2.3.1.176 extracted from

Fu, Y.; Cui, X.; Liu, J.; Zhang, X.; Zhang, H.; Yang, C.; Liu, Q.
Synergistic roles of acyl-CoA binding protein (ACBP1) and sterol carrier protein 2 (SCP2) in Toxoplasma lipid metabolism (2019), Cell. Microbiol., 21, e12970 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Toxoplasma gondii	5829	-

Organism

Organism	UniProt	Comment	Textmining
Toxoplasma gondii	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
tachyzoite	-	Toxoplasma gondii	-

Synonyms

Synonyms	Comment	Organism
TgSCP2	-	Toxoplasma gondii

General Information

General Information	Comment	Organism
malfunction	disruption of either TgACBP1 (acyl-CoA binding protein) or TgSCP2 caused no obviously phenotypic changes, whereas double disruption results in defects in intracellular growth and virulence to mice. TgACBP1 or TgSCP2 disruption alone leads to decreased abundance of C18:1, whereas double disruption results in reduced abundance of C18:1, C22:1, and C24:1. Loss of TgACBP1 and TgSCP2 cause serious defects in production of glycerides and phospholipids. Collectively, TgACBP1 and TgSCP2 play synergistic roles in lipid metabolism in Toxoplasma gondii	Toxoplasma gondii

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Release 2023.1 (January 2023)