Protein Variants | Comment | Organism |
---|---|---|
E315A | 28% of wild-type mitochondrial acyltransferase activity | Mus musculus |
E315Q | 47% of wild-type mitochondrial acyltransferase activity | Mus musculus |
F313A | 17% of wild-type mitochondrial acyltransferase activity | Mus musculus |
F313Y | 88% of wild-type mitochondrial acyltransferase activity | Mus musculus |
R278H | 10% of wild-type mitochondrial acyltransferase activity | Mus musculus |
R278K | 76% of wild-type mitochondrial acyltransferase activity | Mus musculus |
R279A | 101% of wild-type mitochondrial acyltransferase activity | Mus musculus |
R279H | 95% of wild-type mitochondrial acyltransferase activity | Mus musculus |
R279K | 101% of wild-type mitochondrial acyltransferase activity | Mus musculus |
R318H | 2.6% of wild-type mitochondrial acyltransferase activity | Mus musculus |
R318K | 11% of wild-type mitochondrial acyltransferase activity | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyclohexandione | 50 mM, almost complete inhibition of mitochondrial acyltransferase | Mus musculus | |
Phenylglyoxal | 50 mM, approx. 70% inhibition of mitochondrial acyltransferase | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0032 | - |
palmitoyl-CoA | R318A mutant mitochondrial acyltransferase | Mus musculus | |
0.0046 | - |
palmitoyl-CoA | R318K mutant mitochondrial acyltransferase | Mus musculus | |
0.011 | - |
palmitoyl-CoA | wild-type mitochondrial acyltransferase | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q61586 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + sn-glycerol 3-phosphate | - |
Mus musculus | CoA + 1-palmitoyl-sn-glycerol 3-phosphate | - |
? |