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Literature summary for 2.3.1.13 extracted from

  • Van der Westhuizen, F.H.; Pretorius, P.J.; Erasmus, E.
    The utilization of alanine, glutamic acid, and serine as amino acid substrates for glycine N-acyltransferase (2000), J. Biochem. Mol. Toxicol., 14, 102-109.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
benzoylglycine competitive vs. benzoyl-CoA Bos taurus
N-benzoyl-L-alanine competitive vs. benzoyl-CoA Bos taurus
N-benzoyl-L-asparagine competitive vs. benzoyl-CoA Bos taurus
N-benzoyl-L-glutamic acid competitive vs. benzoyl-CoA Bos taurus
N-benzoyl-L-serine competitive vs. benzoyl-CoA Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2
-
glycine acyl donor benzoyl-CoA Bos taurus
6.4
-
glycine acyl donor benzoyl-CoA Homo sapiens
13
-
benzoyl-CoA cosubstrate glycine Homo sapiens
15.2
-
benzoyl-CoA cosubstrate alanine Homo sapiens
41
-
benzoyl-CoA cosubstrate alanine Bos taurus
105
-
benzoyl-CoA cosubstrate glutamine Bos taurus
129
-
asparagine acyl donor benzoyl-CoA Bos taurus
157
-
benzoyl-CoA cosubstrate asparagine Bos taurus
160
-
benzoyl-CoA cosubstrate glycine Bos taurus
353
-
glutamine acyl donor benzoyl-CoA Bos taurus
997
-
alanine acyl donor benzoyl-CoA Homo sapiens
998
-
benzoyl-CoA cosubstrate glutamic acid Bos taurus
1150
-
glutamic acid acyl donor benzoyl-CoA Bos taurus
1573
-
alanine acyl donor benzoyl-CoA Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
-
27000, SDS-PAGE Homo sapiens
36000
-
1 * 36000, SDS-PAGE Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [Āµmol/min/mg] Specific Activity Maximum [Āµmol/min/mg] Comment Organism
0.7
-
-
Homo sapiens
9.7
-
-
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl-CoA + L-alanine
-
Homo sapiens CoA + N-benzoyl-L-alanine
-
?
benzoyl-CoA + L-alanine
-
Bos taurus CoA + N-benzoyl-L-alanine
-
?
benzoyl-CoA + L-asparagine
-
Homo sapiens CoA + N-benzoyl-L-asparagine
-
?
benzoyl-CoA + L-asparagine
-
Bos taurus CoA + N-benzoyl-L-asparagine
-
?
benzoyl-CoA + L-glutamic acid
-
Homo sapiens CoA + N-benzoyl-L-glutamic acid
-
?
benzoyl-CoA + L-glutamic acid
-
Bos taurus CoA + N-benzoyl-L-glutamic acid
-
?
benzoyl-CoA + L-glutamine
-
Homo sapiens CoA + N-benzoyl-L-glutamine
-
?
benzoyl-CoA + L-glutamine
-
Bos taurus CoA + N-benzoyl-L-glutamine
-
?

Subunits

Subunits Comment Organism
monomer 1 * 36000, SDS-PAGE Bos taurus
monomer 27000, SDS-PAGE Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.1
-
N-benzoylglycine
-
Bos taurus
3
-
N-benzoyl-L-asparagine
-
Bos taurus
4.1
-
N-benzoyl-L-serine
-
Bos taurus
7.9
-
N-benzoyl-L-alanine
-
Bos taurus
8
-
N-benzoyl-L-glutamic acid
-
Bos taurus