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Literature summary for 2.1.3.2 extracted from

  • Balbaa, M.; Hammoud, R.; Yusef, H.
    Comparative study of the inhibition of E. coli and murine aspartate transcarbamylase by phenobarbital analogues (2016), Lett. Drug Des. Discov., 13, 276-281 .
No PubMed abstract available
Search for more literature for 2.1.3.2

Inhibitors

Inhibitors Comment Organism Structure
Phenobarbital
-
 Escherichia coli
Phenobarbital
-
 Mus musculus
Thiobarbituric acid most potent inhibitor Escherichia coli
Thiobarbituric acid most potent inhibitor Mus musculus
thymidine
-
 Escherichia coli
thymidine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
carbamoyl phosphate + L-aspartate Mus musculus
-
 phosphate + N-carbamoyl-L-aspartate
-
 ?
carbamoyl phosphate + L-aspartate Escherichia coli
-
 phosphate + N-carbamoyl-L-aspartate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-aspartate
-
 Mus musculus phosphate + N-carbamoyl-L-aspartate
-
 ?
carbamoyl phosphate + L-aspartate
-
 Escherichia coli phosphate + N-carbamoyl-L-aspartate
-
 ?

Synonyms

Synonyms Comment Organism
aspartate transcarbamylase
-
 Mus musculus
aspartate transcarbamylase
-
 Escherichia coli
ATCase
-
 Mus musculus
ATCase
-
 Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.2
-
 pH and temperature not specified in the publication Escherichia coli Thiobarbituric acid
0.3
-
 pH and temperature not specified in the publication Mus musculus Thiobarbituric acid