BRENDA - Enzyme Database
show all sequences of 2.1.1.72

Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity

Ren, X.; Aleshin, M.; Jo, W.J.; Dills, R.; Kalman, D.A.; Vulpe, C.D.; Smith, M.T.; Zhang, L.; Environ. Health Perspect. 119, 771-777 (2011)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
additional information
Homo sapiens
purified recombinant enzyme, in the presence of S-adenosyl-L-methionine and other cofactors, is unable to methylate trivalent inorganic arsenic or monomethylarsonous acid
?
-
-
-
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
Q9Y5N5
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adipose tissue
-
Homo sapiens
-
adrenal gland
-
Homo sapiens
-
artery
intercranial artery
Homo sapiens
-
bile duct
-
Homo sapiens
-
bone marrow
-
Homo sapiens
-
brain
-
Homo sapiens
-
bronchus
-
Homo sapiens
-
colon
-
Homo sapiens
-
duodenum
-
Homo sapiens
-
epididymis
-
Homo sapiens
-
esophagus
-
Homo sapiens
-
heart
-
Homo sapiens
-
HEK-293 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
HL-60 cell
-
Homo sapiens
-
kidney
-
Homo sapiens
-
larynx
-
Homo sapiens
-
leukocyte
-
Homo sapiens
-
liver
-
Homo sapiens
-
lung
-
Homo sapiens
-
lymph node
-
Homo sapiens
-
mammary gland
lowest expression
Homo sapiens
-
muscle
-
Homo sapiens
-
nasal mucosa
-
Homo sapiens
-
optic nerve
-
Homo sapiens
-
ovary
-
Homo sapiens
-
oviduct
-
Homo sapiens
-
palatine uvula
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
parathyroid gland
highest expression
Homo sapiens
-
pericardium
-
Homo sapiens
-
pituicyte
-
Homo sapiens
-
placenta
-
Homo sapiens
-
prostate gland
-
Homo sapiens
-
rectum
-
Homo sapiens
-
salivary gland
-
Homo sapiens
-
seminal vesicle
-
Homo sapiens
-
skin
-
Homo sapiens
-
small intestine
-
Homo sapiens
-
spleen
-
Homo sapiens
-
testis
-
Homo sapiens
-
thymus
-
Homo sapiens
-
thyroid gland
-
Homo sapiens
-
tonsil
-
Homo sapiens
-
urethra
-
Homo sapiens
-
urinary bladder
-
Homo sapiens
-
UROtsa cell
-
Homo sapiens
-
uterine cervix
-
Homo sapiens
-
uterus
-
Homo sapiens
-
vagina
-
Homo sapiens
-
vena cava
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
additional information
purified recombinant enzyme, in the presence of S-adenosyl-L-methionine and other cofactors, is unable to methylate trivalent inorganic arsenic or monomethylarsonous acid
719373
Homo sapiens
?
-
-
-
-
Synonyms
Synonyms
Commentary
Organism
N-6 adenine-specific DNA methyltransferase 1
-
Homo sapiens
N6AMT1
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
additional information
Homo sapiens
purified recombinant enzyme, in the presence of S-adenosyl-L-methionine and other cofactors, is unable to methylate trivalent inorganic arsenic or monomethylarsonous acid
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adipose tissue
-
Homo sapiens
-
adrenal gland
-
Homo sapiens
-
artery
intercranial artery
Homo sapiens
-
bile duct
-
Homo sapiens
-
bone marrow
-
Homo sapiens
-
brain
-
Homo sapiens
-
bronchus
-
Homo sapiens
-
colon
-
Homo sapiens
-
duodenum
-
Homo sapiens
-
epididymis
-
Homo sapiens
-
esophagus
-
Homo sapiens
-
heart
-
Homo sapiens
-
HEK-293 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
HL-60 cell
-
Homo sapiens
-
kidney
-
Homo sapiens
-
larynx
-
Homo sapiens
-
leukocyte
-
Homo sapiens
-
liver
-
Homo sapiens
-
lung
-
Homo sapiens
-
lymph node
-
Homo sapiens
-
mammary gland
lowest expression
Homo sapiens
-
muscle
-
Homo sapiens
-
nasal mucosa
-
Homo sapiens
-
optic nerve
-
Homo sapiens
-
ovary
-
Homo sapiens
-
oviduct
-
Homo sapiens
-
palatine uvula
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
parathyroid gland
highest expression
Homo sapiens
-
pericardium
-
Homo sapiens
-
pituicyte
-
Homo sapiens
-
placenta
-
Homo sapiens
-
prostate gland
-
Homo sapiens
-
rectum
-
Homo sapiens
-
salivary gland
-
Homo sapiens
-
seminal vesicle
-
Homo sapiens
-
skin
-
Homo sapiens
-
small intestine
-
Homo sapiens
-
spleen
-
Homo sapiens
-
testis
-
Homo sapiens
-
thymus
-
Homo sapiens
-
thyroid gland
-
Homo sapiens
-
tonsil
-
Homo sapiens
-
urethra
-
Homo sapiens
-
urinary bladder
-
Homo sapiens
-
UROtsa cell
-
Homo sapiens
-
uterine cervix
-
Homo sapiens
-
uterus
-
Homo sapiens
-
vagina
-
Homo sapiens
-
vena cava
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
additional information
purified recombinant enzyme, in the presence of S-adenosyl-L-methionine and other cofactors, is unable to methylate trivalent inorganic arsenic or monomethylarsonous acid
719373
Homo sapiens
?
-
-
-
-
General Information
General Information
Commentary
Organism
metabolism
the enzyme potentially participates in arsenic metabolism in vivo
Homo sapiens
physiological function
the enzyme plays a significant role in determining susceptibility to arsenic toxicity and carcinogenicity. Overexpression of the enzyme in UROtsa cells increases resistance to arsenic treatment
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
metabolism
the enzyme potentially participates in arsenic metabolism in vivo
Homo sapiens
physiological function
the enzyme plays a significant role in determining susceptibility to arsenic toxicity and carcinogenicity. Overexpression of the enzyme in UROtsa cells increases resistance to arsenic treatment
Homo sapiens
Other publictions for EC 2.1.1.72
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733356
Pollak
DNA adenine methyltransferase ...
Escherichia coli
Biochemistry
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2181-2192
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733427
Maier
Investigation of the C-termina ...
Caulobacter vibrioides
Biochimie
119
60-67
2015
-
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-
11
-
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1
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2
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1
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11
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1
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734804
Horton
Structures of Escherichia coli ...
Escherichia coli
Nucleic Acids Res.
43
4296-4308
2015
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1
1
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1
1
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733365
Elsawy
Increasing DNA substrate speci ...
Escherichia coli
Biochemistry
79
1262-1266
2014
-
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1
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13
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1
2
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2
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2
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13
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1
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734030
Aranda
Dynamics and reactivity in The ...
Thermus aquaticus
J. Am. Chem. Soc.
136
16227-16239
2014
-
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1
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3
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1
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1
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-
-
-
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-
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735330
Kubicek-Sutherland
Immunization with a DNA adenin ...
Yersinia pseudotuberculosis
Vaccine
32
1451-1459
2014
-
-
-
-
-
-
-
-
-
-
-
1
-
5
-
-
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1
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2
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1
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1
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1
1
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719096
Bonnist
Using the fluorescence decay o ...
Escherichia coli
Biophys. Chem.
160
28-34
2012
-
-
-
-
-
-
-
2
-
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-
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1
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1
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1
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1
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1
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-
-
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-
-
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719550
Erova
DNA adenine methyltransferase ...
Aeromonas hydrophila
Gene
498
280-287
2012
-
-
-
-
-
-
-
-
-
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1
-
6
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1
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2
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1
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1
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1
1
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720029
Pollak
Proximal recognition sites fac ...
Escherichia coli
J. Biol. Chem.
287
22873-22881
2012
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1
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1
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3
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1
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1
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1
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1
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1
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1
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720594
Albu
The Caulobacter crescentus DNA ...
Caulobacter vibrioides
Nucleic Acids Res.
40
1708-1716
2012
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1
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1
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2
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1
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2
1
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1
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2
1
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720595
Drozdz
Novel non-specific DNA adenine ...
Haemophilus influenzae, Haemophilus influenzae biotype aegyptius, Haemophilus influenzae biotype aegyptius ATCC 11116, Haemophilus influenzae Rd (FluMu), Neisseria meningitidis, Neisseria meningitidis Z2491 (Pnme1)
Nucleic Acids Res.
40
2119-2130
2012
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3
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3
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3
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12
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3
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6
3
12
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3
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3
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3
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3
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6
3
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720604
Clark
Characterization of DNA methyl ...
Escherichia coli
Nucleic Acids Res.
40
e29
2012
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734045
Bochow
Bacteriophage adenine methyltr ...
Aliivibrio fischeri, Deinococcus proteolyticus, Deinococcus proteolyticus MRP, Paludibacter propionicigenes, Paludibacter propionicigenes WB4T, Treponema succinifaciens, Treponema succinifaciens DSM 2489, Vibrio anguillarum, Vibrio anguillarum 775, Vibrio campbellii, Vibrio campbellii ATCC BAA-1116, Vibrio cholerae, Vibrio cholerae O395, Vibrio cholerae serotype O1, Vibrio parahaemolyticus, Vibrio parahaemolyticus RIMD, Vibrio phage VHML, Vibrio splendidus, Vibrio splendidus LGP32, Vibrio virus VP882, Vibrio vulnificus, Vibrio vulnificus MO6-24/O
J. Appl. Microbiol.
113
1001-1013
2012
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22
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27
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22
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26
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22
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22
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13
13
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713742
Singh
Identification of holocarboxyl ...
Escherichia coli
Anal. Biochem.
413
55-59
2011
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1
1
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1
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719373
Ren
Involvement of N-6 adenine-spe ...
Homo sapiens
Environ. Health Perspect.
119
771-777
2011
-
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-
-
-
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1
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4
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51
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1
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2
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1
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51
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1
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2
2
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720816
Banerjee
Functional analysis of an acid ...
Helicobacter pylori
PLoS ONE
6
e16810
2011
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1
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2
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1
1
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4
3
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4
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1
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3
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1
2
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1
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1
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744009
Maynard-Smith
Direct and continuous fluores ...
Pyrococcus horikoshii
Anal. Biochem.
418
204-212
2011
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1
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1
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2
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1
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2
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1
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1
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1
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1
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1
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1
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1
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1
1
1
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2
1
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1
1
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-
705175
Chahar
Changing the DNA recognition s ...
Escherichia coli
J. Mol. Biol.
395
79-88
2010
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1
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4
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2
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2
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1
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706888
Sun
DNA adenine methylase is invol ...
Edwardsiella tarda, Edwardsiella tarda TXD1
Vet. Microbiol.
141
149-154
2010
-
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1
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2
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6
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2
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1
1
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719450
Kumar
Characterization of an N6 aden ...
Helicobacter pylori
FEBS J.
277
1666-1683
2010
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1
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2
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1
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2
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3
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1
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1
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1
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2
1
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-
-
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1
1
-
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-
702334
Coffin
Escherichia coli DNA adenine m ...
Escherichia coli
Biochemistry
48
7399-7410
2009
-
-
1
-
-
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-
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2
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2
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1
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1
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1
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2
1
-
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1
-
-
-
-
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1
1
-
-
-
703200
Elsawy
Transition from EcoDam to T4Da ...
Escherichia coli
ChemBioChem
10
2488-2493
2009
-
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1
-
3
-
-
-
-
-
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1
-
1
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1
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1
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1
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-
-
-
-
-
-
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-
-
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-
703759
Adamczyk-Poplawska
Characterization of the NgoAXP ...
Neisseria gonorrhoeae, Neisseria gonorrhoeae FA 1090
FEMS Microbiol. Lett.
300
25-35
2009
-
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1
-
-
-
-
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1
2
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9
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1
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3
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2
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-
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703765
Marinus
Roles of DNA adenine methylati ...
Aeromonas hydrophila, Aggregatibacter actinomycetemcomitans, Brucella abortus, Campylobacter jejuni, Caulobacter vibrioides, Escherichia coli, Klebsiella pneumoniae, Pasteurella multocida, Salmonella enterica, Vibrio cholerae serotype O1, Yersinia enterocolitica
FEMS Microbiol. Rev.
33
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2009
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11
-
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-
-
-
-
-
-
10
10
-
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703875
Lopez-Garrido
Regulation of Salmonella enter ...
Salmonella enterica
Genetics
184
637-649
2009
-
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2
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2
2
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-
704502
Coffin
Escherichia coli DNA adenine m ...
Escherichia coli
J. Biol. Chem.
284
18390-18400
2009
-
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1
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6
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13
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1
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1
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1
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13
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6
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13
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1
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1
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1
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13
-
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-
-
-
-
-
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13
13
705556
Furmanek-Blaszk
M1.Mboll and M2.Mboll type IIS ...
Moraxella bovis
Microbiology
155
1111-1121
2009
-
-
1
-
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1
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2
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3
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1
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1
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2
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-
-
-
-
705646
Chernukhin
-
Purification and properties of ...
Geobacillus stearothermophilus, Geobacillus stearothermophilus SE-589
Mol. Biol.
43
8-15
2009
-
-
1
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3
2
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1
4
-
2
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1
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4
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2
1
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1
1
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1
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3
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2
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1
4
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1
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4
-
1
-
-
1
1
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-
-
-
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-
-
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705744
Ahlert
Insensitivity of chloroplast g ...
Synechocystis sp.
Mol. Gen. Genet.
282
17-24
2009
-
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1
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2
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1
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1
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2
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-
-
-
-
-
-
-
-
-
-
705971
Morgan
The MmeI family: type II restr ...
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) NEB686, Corynebacterium diphtheriae, Corynebacterium striatum, Corynebacterium striatum M82B, Deinococcus radiodurans, Deinococcus radiodurans NEB479, Deinococcus radiodurans RI, Marinobacter hydrocarbonoclasticus, Methylophilus methylotrophus, Neisseria lactamica, Neisseria lactamica ST640 Sange, Neisseria meningitidis, Neisseria meningitidis Z2491, Nitrobacter hamburgensis, Nitrobacter hamburgensis X14, Parvibaculum lavamentivorans, Pseudomonas sp., Pseudomonas sp. OM2164, Psychrobacter sp., Rhodopseudomonas palustris, Rhodopseudomonas palustris BisB5, Rhodospirillum centenum, Rhodospirillum centenum SW, Ruegeria pomeroyi, Sulfurimonas denitrificans, Synechococcus sp. PCC 7002, Synechococcus sp. PCC 7002 PR-6, Trueperella pyogenes
Nucleic Acids Res.
37
5208-5221
2009
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18
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60
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60
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21
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19
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60
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-
60
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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689253
Bogdanova
Transcription regulation of th ...
Aeromonas hydrophila
Nucleic Acids Res.
36
1429-1442
2008
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1
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-
-
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1
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1
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1
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1
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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694455
Morgan
MmeI: a minimal Type II restri ...
Methylophilus methylotrophus
Nucleic Acids Res.
36
6558-6570
2008
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-
1
-
-
-
-
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1
2
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1
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1
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2
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1
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1
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1
2
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1
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-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
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694457
Humbert
The Helicobacter pylori HpyAXI ...
Helicobacter pylori, Helicobacter pylori NSH57
Nucleic Acids Res.
36
6893-6906
2008
-
-
1
-
-
-
-
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2
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5
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2
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3
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1
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2
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-
-
-
2
-
-
-
-
-
-
-
-
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-
1
1
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-
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702115
Jois
Role of histidine residues in ...
Escherichia coli
Biochem. J.
410
543-553
2008
-
-
1
-
2
-
2
-
-
-
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1
1
1
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-
1
-
-
-
-
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2
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3
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-
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1
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2
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2
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1
1
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1
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-
-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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702628
Kumar
Activation and inhibition of D ...
Escherichia coli
Bioorg. Med. Chem.
16
2276-2285
2008
1
-
-
-
-
-
3
-
-
-
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1
-
1
-
-
-
-
-
-
-
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1
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5
-
-
-
-
-
-
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1
-
1
1
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-
-
-
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1
3
1
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-
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1
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-
-
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-
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703347
Low
Clocks and switches: bacterial ...
Caulobacter vibrioides, Escherichia coli, Salmonella enterica, Yersinia pseudotuberculosis
Curr. Opin. Microbiol.
11
106-112
2008
-
-
-
-
-
-
-
-
-
-
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4
-
4
-
-
-
-
-
-
-
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4
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12
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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-
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4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
704168
Bang
Structural and dynamics study ...
Escherichia coli
J. Am. Chem. Soc.
130
17688-17696
2008
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-
-
-
-
-
-
-
-
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1
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2
-
-
-
-
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1
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2
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-
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-
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1
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
704282
Jakomin
Regulation of the Salmonella e ...
Salmonella enterica
J. Bacteriol.
190
7406-7413
2008
-
-
-
-
-
-
-
-
-
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1
-
5
-
-
-
-
-
-
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1
-
2
-
-
-
-
-
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1
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704430
Coffin
Modulation of Escherichia coli ...
Escherichia coli
J. Biol. Chem.
283
20106-20116
2008
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-
1
-
-
-
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2
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1
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2
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1
-
-
-
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1
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2
-
-
-
2
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
2
-
-
-
1
-
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-
1
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
705101
Jeon
DNA adenine methylation of sam ...
Amoeba proteus, Amoeba proteus D
J. Microbiol.
46
564-570
2008
-
-
-
-
-
-
-
-
-
-
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2
-
2
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-
-
-
-
-
-
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2
-
1
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-
-
-
-
-
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-
-
-
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-
-
-
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2
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-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
705127
Peterson
Competitive Lrp and Dam assemb ...
Escherichia coli
J. Mol. Biol.
383
92-105
2008
-
-
-
-
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1
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1
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1
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2
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1
-
-
-
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1
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2
-
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-
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-
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-
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1
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1
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1
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1
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
671124
Kapetaniou
Purification, crystallization ...
Geobacillus stearothermophilus
Acta Crystallogr. Sect. F
63
12-14
2007
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1
1
-
-
-
-
-
-
-
-
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2
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1
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-
-
-
-
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2
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1
-
1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676746
Seshasayee
An assessment of the role of D ...
Escherichia coli
PLoS ONE
2
e273
2007
-
1
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1
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-
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-
-
-
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1
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1
-
2
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1
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1
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
684558
Mruk
A rapid and efficient method f ...
Citrobacter sp., Citrobacter sp. RFL231, Geobacillus stearothermophilus 14P, Geobacillus stearothermophilus
Appl. Environ. Microbiol.
73
4286-4293
2007
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2
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1
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8
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2
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1
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-
-
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-
-
-
-
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671878
Bheemanaik
Structure, function and mechan ...
Caulobacter vibrioides, Enterobacter cloacae, Escherichia coli, Escherichia virus T4, Klebsiella pneumoniae, Moraxella bovis, Rhodobacter sphaeroides, Streptococcus pneumoniae, Thermus aquaticus
Biochem. J.
399
177-190
2006
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6
1
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1
27
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9
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9
6
39
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45
-
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-
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-
-
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9
-
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6
1
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1
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27
-
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-
-
-
-
-
-
-
9
6
-
-
-
45
-
-
-
-
-
-
-
-
-
-
673988
Erova
DNA adenine methyltransferase ...
Aeromonas hydrophila, Aeromonas hydrophila SSU
Infect. Immun.
74
410-424
2006
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1
1
-
1
-
-
-
-
-
2
-
-
10
-
-
1
-
-
-
-
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2
1
2
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-
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1
1
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-
1
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2
-
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1
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-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673989
Erova
Mutations within the catalytic ...
Aeromonas hydrophila, Aeromonas hydrophila SSU
Infect. Immun.
74
5763-5772
2006
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1
1
-
3
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
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2
-
2
-
-
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-
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-
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1
1
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-
3
-
-
-
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-
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-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674306
Faelker
Altered Ca(2+) regulation of Y ...
Yersinia enterocolitica
J. Bacteriol.
188
7072-7081
2006
-
1
-
-
-
-
-
-
-
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-
-
-
5
-
-
-
-
-
-
-
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2
-
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1
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675380
Horton
Structure and substrate recogn ...
Escherichia coli
J. Mol. Biol.
358
559-570
2006
-
1
1
1
7
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
7
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676206
Obarska
Structural model for the multi ...
Escherichia coli
Nucleic Acids Res.
34
1992-2005
2006
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1
-
-
6
-
-
-
-
-
-
-
-
1
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-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
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-
1
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676217
Thomas
Dimerization of the bacterial ...
Rhodobacter sphaeroides
Nucleic Acids Res.
34
806-815
2006
-
1
1
-
1
-
-
4
-
-
2
-
-
1
-
-
1
-
-
-
-
1
1
1
2
-
-
-
2
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
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4
-
-
2
-
-
-
-
1
-
-
-
1
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
658407
Horton
Transition from nonspecific to ...
Escherichia coli, Escherichia virus T4
Cell
121
349-361
2005
-
-
-
-
10
-
1
-
-
-
-
2
-
4
-
-
-
-
-
-
-
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5
2
4
-
-
-
-
-
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-
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-
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-
-
10
-
-
1
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2
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-
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-
-
-
5
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664054
Baskunov
Effects of benzo[a]pyrene-deox ...
Escherichia coli
Biochemistry
44
1054-1066
2005
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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1
-
2
-
-
-
-
-
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-
-
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1
-
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-
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-
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672294
Hattman
DNA-[adenine] methylation in l ...
Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Chlamydomonas reinhardtii, Chlorella sp., Drosophila melanogaster, Homo sapiens, Leishmania major, Oxytricha fallax, Paramecium aurelia, Peridinium triquetrum, Plasmodium falciparum, Plasmodium knowlesi, Plasmodium yoelii, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Stylonychia mytilus, Tetrahymena thermophila
Biochemistry (Moscow)
70
550-558
2005
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18
1
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1
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-
-
-
-
-
-
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26
-
-
1
-
-
-
-
-
1
-
37
-
-
-
-
-
-
-
-
-
-
-
-
18
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674250
Robbins-Manke
Analysis of global gene expres ...
Escherichia coli
J. Bacteriol.
187
7027-7037
2005
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1
-
-
1
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-
-
-
-
-
-
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2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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675828
Faelker
DNA methylation in Yersinia en ...
Escherichia coli, Yersinia enterocolitica
Microbiology
151
2291-2299
2005
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1
2
-
2
-
-
-
-
-
1
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6
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-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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676752
Radlinska
Cloning and preliminary charac ...
Enterococcus faecalis
Pol. J. Microbiol.
54
249-252
2005
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1
1
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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658497
Simala-Grant
Characterization of the DNA ad ...
Helicobacter pylori
Curr. Microbiol.
49
47-54
2004
-
-
1
-
1
-
-
-
-
-
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1
-
2
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-
-
-
2
-
2
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-
-
-
-
-
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-
-
-
-
-
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1
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-
1
-
-
-
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-
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1
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-
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-
-
-
2
-
-
-
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-
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659040
Kossykh
A DNA adenine methyltransferas ...
Escherichia coli
J. Bacteriol.
186
2061-2067
2004
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1
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1
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6
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1
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-
-
-
-
2
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5
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
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659422
Mashhoon
Functional characterization of ...
Escherichia coli
J. Biol. Chem.
279
52075-52081
2004
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1
1
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3
2
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2
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1
1
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-
-
-
2
-
1
1
-
-
1
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
3
-
2
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-
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1
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1
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-
-
-
2
-
1
-
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1
1
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-
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-
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659715
Liebert
Stopped-flow and mutational an ...
Escherichia coli
J. Mol. Biol.
341
443-454
2004
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-
1
-
4
-
-
1
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1
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2
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1
1
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-
-
-
3
1
3
1
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
1
-
-
-
1
-
-
-
1
-
-
-
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3
1
1
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-
1
1
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-
-
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-
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659905
Zinoviev
-
Molecular enzymology of phage ...
Escherichia virus T4
Mol. Biol.
38
737-751
2004
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-
-
-
-
-
-
1
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3
1
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1
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1
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-
-
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2
2
3
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-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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1
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3
1
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-
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-
-
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2
2
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-
-
-
-
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660031
Zinoviev
Symmetry elements in DNA struc ...
Escherichia coli, Escherichia virus T4
Nucleic Acids Res.
32
3930-3934
2004
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-
-
-
-
-
-
2
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2
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2
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-
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-
-
-
-
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4
-
10
2
-
-
-
2
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
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2
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-
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2
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-
-
-
-
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4
-
2
-
-
-
2
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485564
Roberts
REBASE: restriction enzymes an ...
Bacteria
Nucleic Acids Res.
31
418-420
2003
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-
-
-
-
-
-
-
-
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1
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1
-
1
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-
-
-
-
-
-
-
-
-
-
-
-
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-
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1
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-
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-
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659200
Malygin
DNA (cytosine-N4-)- and -(aden ...
Bacillus amyloliquefaciens
J. Biol. Chem.
278
15713-15719
2003
-
-
-
-
-
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3
1
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1
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2
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1
-
-
-
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2
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2
1
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-
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1
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-
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1
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-
-
-
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-
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3
1
1
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1
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-
-
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2
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1
-
-
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1
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659224
Thomas
Structures of liganded and unl ...
Rhodobacter sphaeroides
J. Biol. Chem.
278
26094-26101
2003
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1
1
1
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1
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1
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1
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-
-
-
-
2
-
3
-
-
-
-
-
-
-
-
-
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-
1
-
1
1
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-
1
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1
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-
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-
-
-
-
-
2
-
-
-
-
-
-
-
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659268
Malygin
Bacteriophage T4Dam (DNA-(aden ...
Escherichia virus T4
J. Biol. Chem.
278
41749-41755
2003
-
-
-
-
-
-
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1
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1
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2
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-
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1
-
-
-
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4
1
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
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4
1
1
-
-
2
1
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-
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-
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659301
Zinoviev
Bacteriophage T4 Dam DNA-(N6-a ...
Escherichia virus T4
J. Biol. Chem.
278
7829-7833
2003
-
-
-
-
-
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1
1
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2
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2
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1
-
-
-
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3
-
5
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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1
-
1
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-
-
2
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-
-
-
-
-
3
-
1
-
-
2
1
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659303
Bheemanaik
Kinetic and catalytic properti ...
Klebsiella pneumoniae
J. Biol. Chem.
278
7863-7874
2003
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1
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2
1
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1
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2
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1
1
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1
2
1
3
1
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3
1
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2
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1
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2
2
1
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2
1
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1
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1
2
1
1
-
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3
1
-
-
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659920
Hernday
The mechanism by which DNA ade ...
Escherichia coli
Mol. Cell
12
947-957
2003
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-
-
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1
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1
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2
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2
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2
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1
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1
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2
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659989
Yang
Structure of the bacteriophage ...
Escherichia virus T4
Nat. Struct. Biol.
10
849-855
2003
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1
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1
1
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3
1
4
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1
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1
1
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1
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3
1
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485565
Fedoreyeva
N6-Adenine DNA-methyltransfera ...
Triticum aestivum
FEBS Lett.
514
305-308
2002
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-
-
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1
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1
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1
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1
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2
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7
1
1
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1
1
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1
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1
2
1
1
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1
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2
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7
1
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1
1
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485569
Evdokimov
Bacteriophage T4 Dam DNA-[N6-a ...
Escherichia virus T4
J. Biol. Chem.
277
279-286
2002
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1
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3
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1
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485566
Malygin
A dual role for substrate S-ad ...
Escherichia virus T4
Nucleic Acids Res.
29
2361-2369
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1
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1
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1
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485568
Malygin
-
Single turnover kinetics of me ...
Escherichia virus T4
Mol. Biol.
35
56-68
2001
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1
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