Application | Comment | Organism |
---|---|---|
medicine | enzyme activity might represent one factor responsible for variations in the therapeutic or toxic effects of thiopurine and thiopyrimidine drugs used clinically to treat recipients of transplanted kidneys and patients with renal disease such as glomerulonephritis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,4,5-triiodobenzoic acid | - |
Homo sapiens | |
3,4-dimethoxybenzoic acid | - |
Homo sapiens | |
3,5-dichlorobenzoic acid | - |
Homo sapiens | |
3,5-dihydroxy-4-methoxybenzoic acid | - |
Homo sapiens | |
3,5-dimethylbenzoic acid | - |
Homo sapiens | |
3,5-dinitrobenzoic acid | - |
Homo sapiens | |
3-bromo-5-hydroxy-4-methoxybenzoic acid | - |
Homo sapiens | |
3-chloro-5-hydroxy-4-methoxybenzoic acid | - |
Homo sapiens | |
3-hydroxy-4,5-dimethoxybenzoic acid | - |
Homo sapiens | |
3-hydroxy-4-methoxy-5-(dimethylamino)benzoic acid | - |
Homo sapiens | |
3-hydroxy-4-methoxy-5-nitrobenzoic acid | - |
Homo sapiens | |
3-hydroxy-4-methoxybenzoic acid | - |
Homo sapiens | |
3-hydroxy-5-iodo-4-methoxybenzoic acid | - |
Homo sapiens | |
4-hydroxy-3-methoxybenzoic acid | - |
Homo sapiens | |
benzoic acid | substituted benzoic acids, benzoic acid compounds, noncompetitive inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | various thiophenols as substrates, Km 0.0008-0.0078 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a thiopurine | Homo sapiens | enzyme plays an important role in metabolism of heterocyclic sulfhydryl drugs such as 6-thiopurine and 6-thioguanine | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Purification (Comment) | Organism |
---|---|
partially | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 2-aminothiophenol | - |
Homo sapiens | S-adenosyl-L-homocysteine + 2-methylsulfanylphenylamine | - |
? | |
S-adenosyl-L-methionine + 2-bromothiophenol | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-bromo-2-methylsulfanylbenzene | - |
? | |
S-adenosyl-L-methionine + 2-methoxythiophenol | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-methoxy-2-methylsulfanylbenzene | - |
? | |
S-adenosyl-L-methionine + 3-methoxythiophenol | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-methylsulfanyl-3-methoxybenzene | - |
? | |
S-adenosyl-L-methionine + 4-(aminomethoxy)thiophenol | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-aminomethoxy-4-methylsulfanylbenzene | - |
? | |
S-adenosyl-L-methionine + 4-bromothiophenol | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-bromo-4-methylsulfanylbenzene | - |
? | |
S-adenosyl-L-methionine + 4-chlorothiophenol | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-chloro-4-methylsulfanylbenzene | - |
? | |
S-adenosyl-L-methionine + 4-fluorothiophenol | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-fluoro-4-methylsulfanylbenzene | - |
? | |
S-adenosyl-L-methionine + 4-methoxythiophenol | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-methoxy-4-methylsulfanylbenzene | - |
? | |
S-adenosyl-L-methionine + 4-methylthiophenol | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-methyl-4-methylsulfanylbenzene | - |
? | |
S-adenosyl-L-methionine + 4-nitrothiophenol | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-methylsulfanyl-4-nitrobenzene | - |
? | |
S-adenosyl-L-methionine + 4-thiobenzoate | - |
Homo sapiens | S-adenosyl-L-homocysteine + 4-methylsulfanyl benzoate | - |
? | |
S-adenosyl-L-methionine + 6-thiopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylthiopurine | - |
? | |
S-adenosyl-L-methionine + a thiopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
S-adenosyl-L-methionine + a thiopurine | enzyme plays an important role in metabolism of heterocyclic sulfhydryl drugs such as 6-thiopurine and 6-thioguanine | Homo sapiens | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |