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Literature summary for 2.1.1.61 extracted from

  • He, Z.; Sun, S.; Waqas, M.; Zhang, X.; Qian, F.; Cheng, C.; Zhang, M.; Zhang, S.; Wang, Y.; Tang, M.; Li, H.; Chai, R.
    Reduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitro (2016), Sci. Rep., 6, 29621 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine the enzyme is a target for the prevention of aminoglycoside-induced hair cell death Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cochlear hair cell
-
 Mus musculus
-
HEI-OC1 cell
-
 Mus musculus
-

Subunits

Subunits Comment Organism
? x * 46000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
MTO2
-
 Mus musculus
MTU1
-
 Mus musculus
TRMU
-
 Mus musculus
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus enzyme expression is significantly decreased after 24 h neomycin treatment down

General Information

General Information Comment Organism
malfunction cell death and apoptosis are significantly increased after neomycin injury in cells with downregulated enzyme expression Mus musculus
physiological function the enzyme regulates mitochondrial function and reactive oxygen species levels Mus musculus