Inhibitors | Comment | Organism | Structure |
---|---|---|---|
p-chloromercuribenzoate | - |
Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.046 | - |
S-adenosyl-L-methionine | - |
Bos taurus | |
0.054 | - |
N-acetylserotonin | - |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetylserotonin + S-adenosyl-L-methionine | Bos taurus | formation of the hormone melatonin | S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine | - |
? | |
N-acetylserotonin + S-adenosyl-L-methionine | Felis catus | formation of the hormone melatonin | S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine | - |
? | |
N-acetylserotonin + S-adenosyl-L-methionine | Macaca mulatta | formation of the hormone melatonin | S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Felis catus | - |
- |
- |
Macaca mulatta | - |
monkey | - |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | not | Bos taurus | - |
brain | not | Felis catus | - |
brain | not | Macaca mulatta | - |
pineal gland | - |
Bos taurus | - |
pineal gland | - |
Felis catus | - |
pineal gland | - |
Macaca mulatta | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
enzyme assay | Bos taurus |
additional information | - |
enzyme assay | Felis catus |
additional information | - |
enzyme assay | Macaca mulatta |
Storage Stability | Organism |
---|---|
frozen, stable for several weeks | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxy-N-acetyltryptamine + S-adenosyl-L-methionine | 8% of the activity with N-acetylserotonin | Bos taurus | S-adenosyl-L-homocysteine + N-acetyl-4-methoxytryptamine | - |
? | |
5-hydroxyindoleacetic acid + S-adenosyl-L-methionine | 12% of the activity with N-acetylserotonin | Bos taurus | S-adenosyl-L-homocysteine + 5-methoxyindoleacetic acid | - |
? | |
bufotenine + S-adenosyl-L-methionine | 14% of the activity with N-acetylserotonin | Bos taurus | S-adenosyl-L-homocysteine + N,N-dimethyl-5-hydroxytryptamine | - |
? | |
additional information | absolute requirement for S-adenosylmethionine | Bos taurus | ? | - |
? | |
additional information | absolute requirement for S-adenosylmethionine | Felis catus | ? | - |
? | |
additional information | absolute requirement for S-adenosylmethionine | Macaca mulatta | ? | - |
? | |
N-acetylserotonin + S-adenosyl-L-methionine | formation of the hormone melatonin | Bos taurus | S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine | - |
? | |
N-acetylserotonin + S-adenosyl-L-methionine | formation of the hormone melatonin | Felis catus | S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine | - |
? | |
N-acetylserotonin + S-adenosyl-L-methionine | formation of the hormone melatonin | Macaca mulatta | S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine | - |
? | |
N-methylserotonin + S-adenosyl-L-methionine | 9% of the activity with N-acetylserotonin | Bos taurus | S-adenosyl-L-homocysteine + N-methyl-5-methoxytryptamine | - |
? | |
S-adenosyl-L-methionine + N-acetylserotonin | - |
Bos taurus | S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine | - |
? | |
S-adenosyl-L-methionine + N-acetylserotonin | - |
Felis catus | S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine | - |
? | |
S-adenosyl-L-methionine + N-acetylserotonin | - |
Macaca mulatta | S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine | - |
? | |
serotonin + S-adenosyl-L-methionine | 7% of the activity with N-acetylserotonin | Bos taurus | S-adenosyl-L-homocysteine + 5-methoxytryptamine | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8.3 | - |
Bos taurus |