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Literature summary for 2.1.1.373 extracted from

  • Zheng, Y.; Wang, J.; Zhou, S.; Zhang, Y.
    Liu, J.; Xue, C.-X.; Williams, B.T.; Zhao, X.; Zhao, L.; Zhu, X.-Y.; Sun, C.; Zhang, H.-H.; Xiao, T.; Yang, G.-P.; Todd, J.D.; Zhang, X.-H. Bacteria are important dimethylsulfoniopropionate producers in marine aphotic and high-pressure environments (2020), Nat. Commun., 11, 4658 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate uncultured bacterium the enzyme is involved in biosynthesis of dimethylsulfoniopropionate S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate
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 ?

Organism

Organism UniProt Comment Textmining
uncultured bacterium
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate
-
 uncultured bacterium S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate
-
 ?
S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate the enzyme is involved in biosynthesis of dimethylsulfoniopropionate uncultured bacterium S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate
-
 ?

Synonyms

Synonyms Comment Organism
dsyB
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 uncultured bacterium

General Information

General Information Comment Organism
malfunction metagenome data show that bacterial dsyB mutants are less tolerant of deep ocean pressures than wild-type strains uncultured bacterium
physiological function the enzyme is involved in biosynthesis of the marine osmolyte dimethylsulfoniopropionate (DMSP). The physiological function for DMSP in hydrostatic pressure protection. Bacteria are key DMSP producers in deep seawater and sediment. The genetic potential for bacterial DMSP synthesis via the dsyB gene and its transcription is greater in the deep ocean, and is highest in the sediment.s DMSP catabolic potential is present throughout the trench waters, but is less prominent below 8000 m, perhaps indicating a preference to store DMSP in the deep for stress protection. Deep ocean bacterial isolates show enhanced DMSP production under increased hydrostatic pressure. No eukaryotic DMSP synthesis genes are detected in any metagenomes, even from the surface waters uncultured bacterium