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Literature summary for 2.1.1.366 extracted from

  • Kato, M.; Takemoto, K.; Shinkai, Y.
    A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing (2018), Nat. Commun., 9, 1683 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine Setdb1 has a constant role in endogenous retrovirus silencing. Distinctive sets of endogenous retroviruses are reactivated in different types of Setdb1-deficient somatic cells, including the VL30-class of endogenous retroviruses in mouse embryonic fibroblasts. A viral defense response is induced in immortalized Setdb1 knock-out embryonic fibroblasts Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus O88974
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-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
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 Mus musculus
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General Information

General Information Comment Organism
physiological function Setdb1 has a constant role in endogenous retrovirus silencing. Distinctive sets of endogenous retroviruses are reactivated in different types of Setdb1-deficient somatic cells, including the VL30-class of endogenous retroviruses in mouse embryonic fibroblasts. A viral defense response is induced in immortalized Setdb1 knock-out embryonic fibroblasts Mus musculus