Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.366 extracted from

  • Kato, M.; Takemoto, K.; Shinkai, Y.
    A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing (2018), Nat. Commun., 9, 1683.
    View publication on PubMed
Search for more literature for 2.1.1.366

Application

Application Comment Organism
medicine Setdb1 has a constant role in endogenous retrovirus silencing. Distinctive sets of endogenous retroviruses are reactivated in different types of Setdb1-deficient somatic cells, including the VL30-class of endogenous retroviruses in mouse embryonic fibroblasts. A viral defense response is induced in immortalized Setdb1 knock-out embryonic fibroblasts Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus O88974
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
-
 Mus musculus
-

General Information

General Information Comment Organism
physiological function Setdb1 has a constant role in endogenous retrovirus silencing. Distinctive sets of endogenous retroviruses are reactivated in different types of Setdb1-deficient somatic cells, including the VL30-class of endogenous retroviruses in mouse embryonic fibroblasts. A viral defense response is induced in immortalized Setdb1 knock-out embryonic fibroblasts Mus musculus