Literature summary for 2.1.1.366 extracted from

Cao, N.; Yu, Y.; Zhu, H.; Chen, M.; Chen, P.; Zhuo, M.; Mao, Y.; Li, L.; Zhao, Q.; Wu, M.; Ye, M.
SETDB1 promotes the progression of colorectal cancer via epigenetically silencing p21 expression (2020), Cell Death Dis., 11, 351 .

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Application

Application	Comment	Organism
medicine	SETDB1 expression is highly amplified in colorectal cancer. SETDB1 downregulation in SW480 and HCT116 cells reduces cell proliferation, migration, invasion, and increased colorectal cancer cells apoptosis. SETDB1 overexpression promotes colorectal cancer cells proliferation, migration, and invasion. High expression of SETDB1 is associated with a more aggressive phenotype in vitro. Cell cycle is arrested in G1 phase after SETDB1 silencing. Depletion of SETDB1 in vivo suppresses colorectal cancer cells proliferation. p21 is the target of SETDB1. After transfection with siSETDB1, expression of p21 s distinctly increased. Expression of p21 is significantly decreased after overexpression of SETDB1. SETDB1 can bind to the promoter of p21 and regulate its H3K9me3 enrichment level. Silencing of SETDB1 inhibits colorectal cancer tumorigenesis in vivo	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q15047	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HCT-116 cell	-	Homo sapiens	-
SW-480 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)