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Literature summary for 2.1.1.354 extracted from
- Distinct functions of H3K4 methyltransferases in normal and malignant hematopoiesis (2017), Curr. Opin. Hematol., 24, 322-328 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4 | Mus musculus | overall reaction | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4 | overall reaction | Mus musculus | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| H3K4 methyltransferase | - |
Mus musculus |
| histone H3, lysine 4 methyltransferase | - |
Mus musculus |
| KMT2A | - |
Mus musculus |
| KMT2B | - |
Mus musculus |
| KMT2C | - |
Mus musculus |
| KMT2D | - |
Mus musculus |
| KMT2F | - |
Mus musculus |
| KMT2G | - |
Mus musculus |
| MLL1 | - |
Mus musculus |
| MLL2 | - |
Mus musculus |
| MLL3 | - |
Mus musculus |
| MLL4 | - |
Mus musculus |
| Setd1A | - |
Mus musculus |
| Setd1B | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | Mll1 knockout is embryonic lethal and affects development of the hematopoietic system. Germ-line deletions of Mll2 result in delayed development early in embryogenesis, neural tube defects and widespread apoptosis. Knockdown of Mll3 or knockout of Mll4 in hematopoietic stem/multipotent progenitor cells (HSPCs) results in impaired differentiation of HSPCs and increased HSPC numbers. Erythroid-specific Setd1a deletion partially blocked erythropoiesis, resulting in mild anemia | Mus musculus |
| physiological function | MLL3 and MLL4 act as tumor supressors in leukemia | Mus musculus |
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Release 2023.1 (January 2023)
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