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Literature summary for 2.1.1.348 extracted from
- Modification of N6-methyladenosine RNA methylation on heat shock protein expression (2018), PLoS ONE, 13, e0198604 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q86U44 and Q9HCE5 | Q86U44: METTL3, N6-adenosine-methyltransferase 70 kDa subunit. Q9HCE5: METTL14, N6-adenosine-methyltransferase non-catalytic subunit | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hep-G2 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| METTL3 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | m6A methyltransferases METTL3 mRNA is decreased in responses to heat shock stress in HepG2 cells | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | METTL3 knockdown significantly changes HSP70, HSP60, and HSP27 mRNA expression in HepG2 cells using siRNA. mRNA lifetime is not impacted. Knockdown of METTL3 changes the methylation patterns of heat shock proteins transcript | Homo sapiens |
| physiological function | m6A RNA methylation by METTL3 regulates heat shock protein gene expression | Homo sapiens |
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Release 2023.1 (January 2023)
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