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Literature summary for 2.1.1.348 extracted from

  • Xia, T.; Wu, X.; Cao, M.; Zhang, P.; Shi, G.; Zhang, J.; Lu, Z.; Wu, P.; Cai, B.; Miao, Y.; Jiang, K.
    The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion (2019), Pathol. Res. Pract., 215, 152666 .
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q86U44
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Source Tissue

Source Tissue Comment Organism Textmining
BxPC-3 cell
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 Homo sapiens
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HPDE6-C7 cell
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 Homo sapiens
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MiaPaCa-2 cell
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 Homo sapiens
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pancreatic cancer cell line
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
METTL3
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 Homo sapiens

General Information

General Information Comment Organism
drug target METTL3 is probably involved in pancreatic carcinogenesis. It could eventually be a prognostic marker or a therapeutic target for pancreatic cancer Homo sapiens
malfunction METTL3 knockdown in MIA PaCa-2 and BxPC-3 cells decreases RNA m6A modifications. Cell proliferation, invasion, and migration are decreased by METTL3 knockdown in cancerous cell lines Homo sapiens
physiological function the enzyme (METTL3) promotes pancreatic cancer cell proliferation and invasion. High METTL3 expression is associated with high pathological stage. Survival is better in patients with low METTL3 expression compared with those with high MTTL3 expression Homo sapiens