Literature summary for 2.1.1.348 extracted from

Lee, H.; Bao, S.; Qian, Y.; Geula, S.; Leslie, J.; Zhang, C.; Hanna, J.H.; Ding, L.
Stage-specific requirement for Mettl3-dependent m6A mRNA methylation during haematopoietic stem cell differentiation (2019), Nat. Cell Biol., 21, 700-709 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8C3P7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + adenine in mRNA	Myc is a direct target of m6A in gaematopoietic stem cells	Mus musculus	S-adenosyl-L-homocysteine + N6-methyladenine in mRNA	-	?

Synonyms

Synonyms	Comment	Organism
METTL3	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	deleting the enzyme (Mettl3) from the adult haematopoietic system leads to an accumulation of haematopoietic stem cell in the bone marrow and marked reduction of reconstitution potential due to a blockage of haematopoietic stem cell differentiation. Deleting Mettl3 from myeloid cells using Lysm-cre does not impact myeloid cell number or function. m6A sequencing reveals 2073 genes with significant m6A modification in haematopoietic stem cells	Mus musculus
physiological function	the enzyme plays a key role of m6A in governing haematopoietic stem cell differentiation	Mus musculus

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Release 2023.1 (January 2023)