Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8C3P7 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
METTL3 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | m6A methylated RNA level and its N6-methyladenosine methylase METTL3 are consistently up-regulated in the liver tissues from patients with type 2 diabetes. The m6A methylated RNA and METTL3 levels are up-regulated in mouse with 16 weeks high-fat diet, compared with mice fed a standard chow diet | up |
General Information | Comment | Organism |
---|---|---|
malfunction | hepatocyte-specific knockout of the enzyme (METTL3) in mice fed a high-fat diet improves insulin sensitivity and decreases fatty acid synthesis. Furthermore, mechanism analysis demonstrates that METTL3 silence decreases the m6A methylated and total mRNA level of fatty acid synthase (Fasn), subsequently inhibits fatty acid metabolism | Mus musculus |
physiological function | the enzyme (METTL3) inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism | Mus musculus |