Literature summary for 2.1.1.345 extracted from

Fricke, J.; Sherwood, A.; Kargbo, R.; Orry, A.; Blei, F.; Naschberger, A.; Rupp, B.; Hoffmeister, D.
Enzymatic route toward 6-methylated baeocystin and psilocybin (2019), ChemBioChem, 20, 2824-2829 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Psilocybe cubensis

Protein Variants

Protein Variants	Comment	Organism
D161A	the variant is as active as the wild-type enzyme in in vitro assays	Psilocybe cubensis
N183A	the variant is catalytically inactive	Psilocybe cubensis
R75A	the variant is catalytically inactive	Psilocybe cubensis
S196A	inactive variant	Psilocybe cubensis
Y187A	the variant is catalytically inactive	Psilocybe cubensis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2 S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate	Psilocybe cubensis	-	2 S-adenosyl-L-homocysteine + psilocybin	-	?

Organism

Organism	UniProt	Comment	Textmining
Psilocybe cubensis	P0DPA9	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Psilocybe cubensis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate	-	Psilocybe cubensis	2 S-adenosyl-L-homocysteine + psilocybin	-	?

Synonyms

Synonyms	Comment	Organism
PsiM	-	Psilocybe cubensis

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Release 2023.1 (January 2023)