Literature summary for 2.1.1.34 extracted from

Freund, I.; Buhl, D.K.; Boutin, S.; Kotter, A.; Pichot, F.; Marchand, V.; Vierbuchen, T.; Heine, H.; Motorin, Y.; Helm, M.; Dalpke, A.H.; Eigenbrod, T.
2-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms (2019), RNA, 25, 869-880 .

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Escherichia coli BW25113	-	-	-
Homo sapiens	Q13395	-	-
Saccharomyces cerevisiae	-	-	-

General Information	Comment	Organism
physiological function	mutation of TARBP1 results in loss of Gm18 within tRNA. Lack of Gm18 across results in increased immunostimulation of peripheral blood mononuclear cells when activated by tRNA preparations.Lack of Gm18 in yeasts and human cells does not affect immunostimulation by whole RNA preparations	Homo sapiens
physiological function	mutation of TrmH results in loss of Gm18 within tRNA. Lack of 2'-O-methyltransferase TrmH enhances immune stimulatory properties by whole cellular RNA. When using live Escherichia coli bacteria, lack of TrmH does not affect overall immune stimulation although a defined TLR8/RNA-dependent gene expression signature is found upon Escherichia coli infection	Escherichia coli
physiological function	mutation of TrmH results in loss of Gm18 within tRNA. Lack of Gm18 across results in increased immunostimulation of peripheral blood mononuclear cells when activated by tRNA preparations. Lack of Gm18 in yeasts and human cells does not affect immunostimulation by whole RNA preparations	Saccharomyces cerevisiae