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Literature summary for 2.1.1.319 extracted from

  • Zhang, Y.; Wang, D.; Zhang, M.; Wei, H.; Lu, Y.; Sun, Y.; Zhou, M.; Gu, S.; Feng, W.; Wang, H.; Zeng, J.; Gong, A.; Xu, M.
    Protein arginine methyltransferase 1 coordinates the epithelial-mesenchymal transition/proliferation dichotomy in gastric cancer cells (2018), Exp. Cell Res., 362, 43-50 .
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q99873
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-

Source Tissue

Source Tissue Comment Organism Textmining
gastric cancer cell line AGS, MGC803, BGC823 and SGC7901 Homo sapiens
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Synonyms

Synonyms Comment Organism
PRMT1
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 Homo sapiens
protein arginine methyltransferase 1
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is up-regulated and promotes migration, invasion and proliferation in wide range of cancers up

General Information

General Information Comment Organism
drug target given the dual functions of PRMT1 (promotion of migration and invasion and inhibition of proliferation in gastric cancer cells), it is a potential drug target of gastric cancer with extreme caution Homo sapiens
physiological function important roles of the enzyme (PRMT1) in progression of gastric cancer. The enzyme is up-regulated and promotes migration, invasion and proliferation in wide range of cancers. PRMT1 promotes migration and invasion and inhibits proliferation in gastric cancer cells,whereas PRMT1 knockdown reverses the above abilities. PRMT1 reduces the expression of epithelial marker E-cadherin and increases the expression of mesenchymal markers including N-cadherin, Vimentin, snail and beta-catenin in gastric cancer cells. PRMT1 silencing promotes the phosphorylation of LATS1, and then induces YAP phosphorylation, while overexpression of PRMT1 down-regulates the phosphorylation of LATS1 and YAP, indicating that PRMT1 inhibits EMT probably via Hippo signaling Homo sapiens